1. Gene
  2. ILK - integrin linked kinase Gene

ILK - integrin linked kinase Gene

中文名称:整合素连接激酶

种属: Homo sapiens

同用名: P59; ILK-1; ILK-2; p59ILK; HEL-S-28

基因 ID: 3611 | 基因类型: protein coding

关于 ILK

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,603,774-6,610,870 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 23 paralogues. Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues.

功能概要

该基因编码一种具有激酶样结构域和四个锚蛋白样重复序列的蛋白质。编码的蛋白质在细胞膜上与 β 整合素的细胞质结构域结合,在此处调节整合素介导的信号转导。这种蛋白质的活性在上皮到间充质的转化中很重要,并且这种基因的过度表达与肿瘤生长和转移有关。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 6 月]

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

ILK 基因产物(5)

mRNA Protein Name
NM_001014794.3 NP_001014794.1 integrin-linked protein kinase isoform 1
NM_001014795.3 NP_001014795.1 integrin-linked protein kinase isoform 1
NM_001278441.2 NP_001265370.1 integrin-linked protein kinase isoform 2
NM_001278442.2 NP_001265371.1 integrin-linked protein kinase isoform 3
NM_004517.4 NP_004508.1 integrin-linked protein kinase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
20005845 GOA
enables integrin binding IDA
IDA: 通过直接分析推断
20005845 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
20005845 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11331308 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19118217 GOA
NOT enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
20005845 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
18283114 GOA
located in chromatin IDA
IDA: 通过直接分析推断
17420447 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17420447 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
30254023 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17420447 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ILK 蛋白结构

Ank

Ank: Ankyrin repeat (33 - 64)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (67 - 127)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (194 - 445)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
蛋白主名 其他名称

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase

ILK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ILK Q13418 LIMS1 Homo sapiens P48059-3
Y2H Prey Pooling
32296183
种属内
ILK Q13418 LIMS1 Homo sapiens P48059-3
Y2H Array
32296183
种属内
ILK Q13418 RICTOR Homo sapiens Q6R327
Y2H
18339839
种属内
ILK Q13418 RICTOR Homo sapiens Q6R327
Anti Bait CoIP
18339839
种属内
ILK Q13418 RICTOR Homo sapiens Q6R327
Anti Tag CoIP
18339839
种属内
ILK Q13418 SLC4A1AP Homo sapiens Q9BWU0
Anti Tag CoIP
17553790
种属内
ILK Q13418 SLC4A1AP Homo sapiens Q9BWU0
Pull Down
17553790
种属内
ILK Q13418 ILKAP Homo sapiens Q9H0C8
Anti Bait CoIP
11331582
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Pull Down
19074270
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
35271311
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
BiFC
23877428
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Y2H
11331308
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Pull Down
32707033
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Bait CoIP
17353931
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
X-Ray Diffraction
19074270
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
18339839
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
TAP
23455922
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
GMS
19074270
种属内
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
25852190
种属内
ILK Q13418 SYNPO2 Homo sapiens Q9UMS6
Anti Bait CoIP
21643011
种属内
ILK Q13418 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
ILK Q13418 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
ILK Q13418 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
ILK Q13418 PARVG Homo sapiens Q9HBI0
Y2H Prey Pooling
25416956
种属内
ILK Q13418 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
种属内
ILK Q13418 PARVG Homo sapiens Q9HBI0
Y2H Array
25416956
种属内
ILK Q13418 CASP9 Homo sapiens P55211
Anti Bait CoIP
16936772
种属内
ILK Q13418 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Validated Y2H
25416956
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Prey Pooling
32296183
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
TAP
23455922
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
26496610
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Validated Y2H
32296183
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Array
25416956
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
25852190
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
33961781
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H
11331308
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Array
32296183
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Pooling
16189514
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
BiFC
23877428
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Pull Down
17553790
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Pull Down
32707033
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Prey Pooling
25416956
种属内
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
35271311
种属内
ILK Q13418 CASP8 Homo sapiens Q14790
Anti Bait CoIP
16936772
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Renal Fibrosis
Hyperphosphatemia
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ILK VGNC VGNC:73738
Mus musculus ILK MGD MGI:1195267
Rattus norvegicus ILK RGD RGD:620063
Bos taurus ILK VGNC VGNC:30177
Canis familiaris ILK VGNC VGNC:42001
Felis catus ILK VGNC VGNC:67792
Others ILK NCBI