2. Gene
  3. SYNPO2 - synaptopodin 2 Gene

SYNPO2 - synaptopodin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触足蛋白 2

种属: Homo sapiens

同用名: SYISL

基因 ID: 171024 | 基因类型: protein coding

关于 SYNPO2

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Broad expression in esophagus (RPKM 79.5), prostate (RPKM 71.0) and 14 other tissues.

功能概要

启用 α-辅肌动蛋白结合活性和细丝蛋白结合活性。参与肌动蛋白丝束组装的正调控；细胞迁移的正调控；和 Rho 依赖性蛋白丝氨酸/苏氨酸激酶活性的调节。位于多个细胞成分中，包括 Z 盘；粘着斑；和应力纤维。 [由基因组资源联盟提供，2022 年 4 月]

Enables alpha-actinin binding activity and filamin binding activity. Involved in positive regulation of actin filament bundle assembly; positive regulation of cell migration; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in several cellular components, including Z disc; focal adhesion; and stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

SYNPO2 基因产物(7)

mRNA Protein Name
NM_001128933.3 NP_001122405.1 synaptopodin-2 isoform b
NM_001128934.3 NP_001122406.1 synaptopodin-2 isoform c
NM_001286754.2 NP_001273683.1 synaptopodin-2 isoform d
NM_001286755.2 NP_001273684.1 synaptopodin-2 isoform e
NM_001389263.1 NP_001376192.1 synaptopodin-2 isoform f
NM_001389264.1 NP_001376193.1 synaptopodin-2 isoform g
NM_133477.3 NP_597734.2 synaptopodin-2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-actinin binding IDA
IDA: 通过直接分析推断
20554076 GOA
enables filamin binding IDA
IDA: 通过直接分析推断
20554076 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21643011 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of actin filament bundle assembly IDA
IDA: 通过直接分析推断
24005909 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
22915763 GOA
involved in regulation of Rho-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
22915763 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
20554076 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
20554076 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
20554076 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SYNPO2 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (11 - 84)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1093 a.a.
蛋白主名 其他名称

synaptopodin-2

SYNPO2 intron sense-overlapping lncRNA

SYNPO2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Pull Down
21643011
种属内
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Confocal
21643011
种属内
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Anti Bait CoIP
21643011
种属内
SYNPO2 Q9UMS6 ILK Homo sapiens Q13418
Y2H
21643011
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrotic Syndrome, Type 23

NPHS23

Nephrotic Syndrome Type 23

Nephrotic Syndrome 23
Nephrotic Syndrome, Type 21

NPHS21

Nephrotic Syndrome Type 21

Nephrotic Syndrome 21
Nephrotic Syndrome, Type 22

NPHS22

Nephrotic Syndrome Type 22

Nephrotic Syndrome 22
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Myopathy, Myofibrillar, 2

Alpha-B Crystallinopathy

Myofibrillar Myopathy 2

MFM2

Myopathy, Myofibrillar, Alpha-B Crystallin-Related

Myopathy, Desmin-Related, Associated With Mutation In The Cryab Gene

Myopathy, Myofibrillar, With Or Without Cataract And/Or Cardiomyopathy

Alpha-B Crystallin-Related Late-Onset Myopathy

Alpha-B Crystallin-Related Late-Onset Distal Myopathy

Late-Onset Distal Crystallinopathy

Alpha-B Crystallinopathy With Cataract

Desmin-Related Myopathy With Cataract

Mfm Alpha-B Crystallin-Related

Myofibrillar Myopathy Alpha-B Crystallin-Related

Myofibrillar Myopathy With Or Without Cataract And/Or Cardiomyopathy

Myopathy Cardioskeletal Desmin-Related With Cataract

Myopathy Desmin-Related Associated With Mutation In The Cryab Gene

Myopathy, Cardioskeletal, Desmin-Related, With Cataract

Myopathy, Myofibrillar, Type 2
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Myofibrillar Myopathy

Desmin Related Myopathy

Myotilinopathy

Myopathy, Myofibrillar

Alpha Beta Crystallinopathy

Desmin Storage Myopathy

Desminopathy

Filaminopathy

Protein Surplus Myopathy

Zaspopathy

Myofibrillar Myopathies

Myopathy, Myofibrillar, Desmin-Related

Myopathy, Desmin Storage

Mfm - [Myofibrillar Myopathy]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14098 SYNPO2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14099 SYNPO2L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SYNPO2 VGNC VGNC:78152
Rattus norvegicus SYNPO2 RGD RGD:1564779
Felis catus SYNPO2 VGNC VGNC:65889
Bos taurus SYNPO2 VGNC VGNC:35531
Canis familiaris SYNPO2 VGNC VGNC:47035
Mus musculus SYNPO2 MGD MGI:2153070
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