2. Gene
  3. LIMS1 - LIM zinc finger domain containing 1 Gene

LIMS1 - LIM zinc finger domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 LIM 锌指结构域 1

种属: Homo sapiens

同用名: PINCH; PINCH1; PINCH-1

基因 ID: 3987 | 基因类型: protein coding

关于 LIMS1

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,533,671-108,687,246 (from NCBI)

This gene has 23 transcripts (splice variants), 30 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 18.5), adrenal (RPKM 16.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种衔接蛋白，包含五个 LIM 结构域或双锌指结构域。该蛋白可能通过其 LIM 域介导的与整合素连接激酶的相互作用参与整合素信号传导，在粘着斑块中发现。它也被认为是连接整合素连接激酶和 NCK 衔接蛋白 2 的桥梁，后者参与生长因子受体激酶信号通路。它定位于扩散细胞的外围也表明该蛋白质可能在整合素介导的细胞粘附或扩散中发挥作用。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in Integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

LIMS1 基因产物(16)

mRNA Protein Name
NM_001193482.2 NP_001180411.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform c
NM_001193483.3 NP_001180412.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform d
NM_001193484.2 NP_001180413.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform e
NM_001193485.3 NP_001180414.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform a
NM_001193488.2 NP_001180417.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371494.1 NP_001358423.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform f
NM_001371495.1 NP_001358424.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform g
NM_001371496.1 NP_001358425.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform h
NM_001371497.1 NP_001358426.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform i
NM_001371498.1 NP_001358427.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371499.1 NP_001358428.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform j
NM_001371500.1 NP_001358429.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform k
NM_001394896.1 NP_001381825.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform l
NM_001394897.1 NP_001381826.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform m
NM_001394898.1 NP_001381827.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform n
NM_004987.6 NP_004978.2 LIM and senescent cell antigen-like-containing domain protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10574708 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20926685 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
19074270 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
21390327 GOA
NOT involved in epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
20926685 GOA
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
20926685 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21390327 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
20926685 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21343177 GOA
involved in positive regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
20926685 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
20926685 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20926685 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
20926685 GOA
NOT involved in regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
20926685 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
21343177 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IMP
IMP: 通过突变表型推断
20926685 GOA
colocalizes with focal adhesion IDA
IDA: 通过直接分析推断
19117955 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
20926685 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
21390327 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIMS1 蛋白结构

LIM

LIM: LIM domain (10 - 66)

LIM

LIM: LIM domain (71 - 125)

LIM

LIM: LIM domain (135 - 186)

LIM

LIM: LIM domain (193 - 247)

LIM

LIM: LIM domain (252 - 306)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

LIM and senescent cell antigen-like-containing domain protein 1

LIM and senescent cell antigen-like domains 1

关联疾病

疾病名称 别名
Chromosome 3q13.31 Deletion Syndrome

3q13 Microdeletion Syndrome

Monosomy 3q13

Chromosome 3, Monosomy 3q13

Del(3)(Q13)
Heinz Body Anemias

Heinz Body Anemia

Heinz Body Anemias, Alpha-

HEIBAN

Anemia, Heinz Body

Acquired Heinz Body Anemia
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07668 LIMS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LIMS1 VGNC VGNC:81113
Macaca mulatta LIMS1 VGNC VGNC:74271
Rattus norvegicus LIMS1 RGD RGD:1560732
Bos taurus LIMS1 VGNC VGNC:50211
Mus musculus LIMS1 MGD MGI:1195263
Others LIMS1 NCBI
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