2. Gene
  3. Ilk - integrin linked kinase Gene

Ilk - integrin linked kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ILK-1; ILK-2; ESTM24; p59ILK

基因 ID: 16202 | 基因类型: protein coding

关于 Ilk

功能概要

Predicted to enable several functions, including SH3 domain binding activity; Integrin binding activity; and protein kinase binding activity. Involved in outflow tract morphogenesis; positive regulation of BMP signaling pathway; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including fibroblast migration; nervous system development; and protein kinase B signaling. Located in focal adhesion and lamellipodium. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ILK (Integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ilk 基因产物(2)

mRNA Protein Name
NM_001161724.1 NP_001155196.1 integrin-linked protein kinase
NM_010562.2 NP_034692.2 integrin-linked protein kinase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10574708 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Schwann cell development IMP
IMP: 通过突变表型推断
19349584 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
15831470 MGI
involved in caveola assembly IMP
IMP: 通过突变表型推断
20951348 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
12835312 MGI
acts upstream of or within cell projection organization IMP
IMP: 通过突变表型推断
19349584 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: 通过突变表型推断
12670870 MGI
acts upstream of or within fibroblast migration IMP
IMP: 通过突变表型推断
23658024 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: 通过突变表型推断
19349584 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IGI
IGI: 通过遗传相互作用推断
24719101 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
24719101 MGI
acts upstream of or within nerve development IMP
IMP: 通过突变表型推断
19349584 MGI
acts upstream of neural precursor cell proliferation IGI
IGI: 通过遗传相互作用推断
24719101 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
24719101 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
24131868 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
19349584 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
19349584 MGI
involved in positive regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
20675382 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12835312 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
20675382 MGI
involved in protein localization to cell cortex IMP
IMP: 通过突变表型推断
20951348 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
12432066 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
18325335 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase

beta-integrin-linked kinase

integrin binding protein kinase

Ilk 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ilk O55222 LIMS1 Homo sapiens P48059
Anti Tag CoIP
12432066
种属间
Ilk O55222 LIMS1 Homo sapiens P48059
ELISA
10574708
种属内
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Bait CoIP
19798050
种属内
Ilk O55222 Parva Mus musculus Q9EPC1
Pull Down
19829382
种属内
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Tag CoIP
23612611
种属内
Ilk O55222 Parva Mus musculus Q9EPC1
Anti Tag CoIP
19829382
种属内
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Tag CoIP
23612611
种属内
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Tag CoIP
19829382
种属内
Ilk O55222 Parvb Mus musculus Q9ES46
Anti Bait CoIP
19798050
种属内
Ilk O55222 Stub1 Mus musculus Q9WUD1
Anti Tag CoIP
23612611
种属内
Ilk O55222 Stub1 Mus musculus Q9WUD1
Fluorescence
23612611
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18676 OSU-T315 99.88% 否
HY-113439 12-HETE Inhibitor 95.70% 否
HY-115677 ILK-IN-3 Inhibitor 99.62% 否
HY-18676B ILK-IN-2 99.41% 否
HY-154921 Lactosylceramide (bovine buttermilk) ≥98.0% 否
HY-113439S 12-HETE-d8 Inhibitor ≥98.0% 否
HY-RS06787 ILK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ilk NCBI NCBI:3611
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