2. Gene
  3. Stub1 - STIP1 homology and U-Box containing protein 1 Gene

Stub1 - STIP1 homology and U-Box containing protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Chip; 0610033N24Rik; 2210017D18Rik; 2310040B03Rik

基因 ID: 56424 | 基因类型: protein coding

关于 Stub1

功能概要

Enables protein homodimerization activity; ubiquitin protein Ligase binding activity; and ubiquitin-ubiquitin Ligase activity. Involved in several processes, including cellular response to topologically incorrect protein; positive regulation of ubiquitin-protein transferase activity; and proteolysis involved in cellular protein catabolic process. Acts upstream of or within protein polyubiquitination. Located in Z disc. Used to study autosomal recessive spinocerebellar ataxia 16. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stub1 基因产物(1)

mRNA Protein Name
NM_019719.4 NP_062693.1 E3 ubiquitin-protein ligase CHIP
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16307917 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
16307917 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
21855799 MGI
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
21855799 MGI
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
11435423 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to misfolded protein IMP
IMP: 通过突变表型推断
21855799 MGI
involved in endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
12150907 MGI
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
12150907 MGI
involved in positive regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
12150907 MGI
involved in positive regulation of ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
12150907 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
21855799 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: 通过直接分析推断
11435423 MGI
involved in protein quality control for misfolded or incompletely synthesized proteins IMP
IMP: 通过突变表型推断
21855799 MGI
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
27273569 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27273569 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
18292230 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
20060297 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
19953350 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase CHIP

RING-type E3 ubiquitin transferase CHIP

carboxy terminus of Hsp70-interacting protein

Stub1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Stub1 Q9WUD1 UBE2N Homo sapiens P61088
ITC
16307917
种属内
Stub1 Q9WUD1 Ilk Mus musculus O55222
Pull Down
23612611
种属内
Stub1 Q9WUD1 Ilk Mus musculus O55222
Anti Tag CoIP
23612611
种属内
Stub1 Q9WUD1 Ilk Mus musculus O55222
Anti Bait CoIP
23612611
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13972 STUB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stub1 NCBI NCBI:10273
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