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  2. RSU1 - Ras suppressor protein 1 Gene

RSU1 - Ras suppressor protein 1 Gene

中文名称:Ras 抑制蛋白 1

种属: Homo sapiens

同用名: RSP-1

基因 ID: 6251 | 基因类型: protein coding

关于 RSU1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:16,590,611-16,817,424 (from NCBI)

This gene has 5 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues.

功能概要

该基因编码一种蛋白质,该蛋白质参与 Ras 信号转导通路、生长抑制和神经生长因子诱导的分化过程,如小鼠和人类细胞系研究中所确定。在小鼠中,编码的蛋白质最初是根据其抑制 v-Ras 转化的能力而分离的。已经报道了该基因的多个选择性剪接转录变体;其中一种变异仅在神经胶质瘤中发现。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

RSU1 基因产物(2)

mRNA Protein Name
NM_012425.4 NP_036557.1 ras suppressor protein 1 isoform 1
NM_152724.3 NP_689937.2 ras suppressor protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20926685 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
20926685 GOA
involved in positive regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
20926685 GOA
NOT involved in regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
20926685 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
20926685 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RSU1 蛋白结构

(41 - 56)

LRR_8

LRR_8: Leucine rich repeat (64 - 121)

LRR_1

LRR_1: Leucine Rich Repeat (136 - 156)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (157 - 195)

  • 0
  • 100
  • 200
  • 277 a.a.
蛋白主名 其他名称

ras suppressor protein 1

rsu-1

RSU1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RSU1 Q15404 LIMS1 Homo sapiens P48059
Validated Y2H
25416956
种属内
RSU1 Q15404 LIMS1 Homo sapiens P48059
Anti Tag CoIP
33961781
种属内
RSU1 Q15404 LIMS1 Homo sapiens P48059
Anti Tag CoIP
28514442
种属内
RSU1 Q15404 LIMS1 Homo sapiens P48059
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RSU1 VGNC VGNC:97822
Bos taurus RSU1 VGNC VGNC:57022
Felis catus RSU1 VGNC VGNC:97615
Canis familiaris RSU1 VGNC VGNC:52921
Rattus norvegicus RSU1 RGD RGD:1591781
Mus musculus RSU1 MGD MGI:103040