2. Gene
  3. RHPN1 - rhophilin Rho GTPase binding protein 1 Gene

RHPN1 - rhophilin Rho GTPase binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：rhophilin Rho GTPase 结合蛋白 1

种属: Homo sapiens

同用名: ODF5; RHPN; RHOPHILIN

基因 ID: 114822 | 基因类型: protein coding

关于 RHPN1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,364,255-143,384,221 (from NCBI)

This gene has 3 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in brain (RPKM 2.9), kidney (RPKM 2.5) and 22 other tissues.

功能概要

预计参与信号转导。预计在几个过程的上游或内部起作用，包括粘着斑装配；肾小球滤过；和应力纤维组装的负调节。预测位于质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHPN1 基因产物(1)

mRNA Protein Name
NM_052924.3 NP_443156.2 rhophilin-1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHPN1 蛋白结构

HR1

HR1: Hr1 repeat (36 - 92)

BRO1

BRO1: BRO1-like domain (108 - 509)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (515 - 584)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
蛋白主名 其他名称

rhophilin-1

GTP-Rho-binding protein 1

RHPN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RHPN1 Q8TCX5 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra RHPN1 Q8TCX5 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra RHPN1 Q8TCX5 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra RHPN1 Q8TCX5 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra RHPN1 Q8TCX5 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra RHPN1 Q8TCX5 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra RHPN1 Q8TCX5 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra RHPN1 Q8TCX5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra RHPN1 Q8TCX5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra RHPN1 Q8TCX5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra RHPN1 Q8TCX5 GOLGA2 Homo sapiens Q08379
Anti Tag CoIP
33961781
Intra RHPN1 Q8TCX5 GOLGA2 Homo sapiens Q08379
Anti Tag CoIP
28514442
Intra RHPN1 Q8TCX5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra RHPN1 Q8TCX5 HAP1 Homo sapiens P54257
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 HAP1 Homo sapiens P54257
Y2H Array
32296183
Intra RHPN1 Q8TCX5 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra RHPN1 Q8TCX5 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra RHPN1 Q8TCX5 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra RHPN1 Q8TCX5 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra RHPN1 Q8TCX5 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra RHPN1 Q8TCX5 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra RHPN1 Q8TCX5 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra RHPN1 Q8TCX5 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra RHPN1 Q8TCX5 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra RHPN1 Q8TCX5 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra RHPN1 Q8TCX5 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra RHPN1 Q8TCX5 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra RHPN1 Q8TCX5 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra RHPN1 Q8TCX5 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra RHPN1 Q8TCX5 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tracheal Calcification

Calcification Of Trachea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11961 RHPN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RHPN1 VGNC VGNC:45567
Macaca mulatta RHPN1 VGNC VGNC:76779
Bos taurus RHPN1 VGNC VGNC:33956
Rattus norvegicus RHPN1 RGD RGD:1305688
Felis catus RHPN1 VGNC VGNC:64620
Mus musculus RHPN1 MGD MGI:1098783
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