2. Gene
  3. TUFT1 - tuftelin 1 Gene

TUFT1 - tuftelin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tuftelin 1

种属: Homo sapiens

基因 ID: 7286 | 基因类型: protein coding

关于 TUFT1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,540,309-151,583,583 (from NCBI)

This gene has 6 transcripts (splice variants), 253 orthologues and 3 paralogues. Broad expression in skin (RPKM 29.7), esophagus (RPKM 10.9) and 19 other tissues.

功能概要

Tuftelin 是一种酸性蛋白质，被认为在牙釉质矿化中起作用，并与龋齿易感性有关。它也被认为与适应缺氧、间充质干细胞功能和神经营养因子神经生长因子介导的神经元分化有关。[RefSeq 提供，2014 年 8 月]

Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]

TUFT1 基因产物(3)

mRNA Protein Name
NM_001126337.2 NP_001119809.1 tuftelin isoform 2
NM_001301317.2 NP_001288246.1 tuftelin isoform 3
NM_020127.3 NP_064512.1 tuftelin isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables structural constituent of skin epidermis IMP
IMP: 通过突变表型推断
36689522 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TUFT1 蛋白结构

GCOM2

GCOM2: Putative GRINL1B complex locus protein 2 (166 - 345)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

tuftelin

TUFT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TUFT1 Q9NNX1 KAT5 Homo sapiens Q92993
Validated Y2H
25416956
Intra TUFT1 Q9NNX1 KAT5 Homo sapiens Q92993
Y2H Array
25416956
Intra TUFT1 Q9NNX1 ZYX Homo sapiens Q15942
Y2H Array
31515488
Intra TUFT1 Q9NNX1 ZYX Homo sapiens Q15942
Y2H Array
29892012
Intra TUFT1 Q9NNX1 ZYX Homo sapiens Q15942
Anti Tag CoIP
33961781
Intra TUFT1 Q9NNX1 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra TUFT1 Q9NNX1 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra TUFT1 Q9NNX1 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
Intra TUFT1 Q9NNX1 CEP76 Homo sapiens Q8TAP6
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 2

Enamel Hypoplasia, X-Linked

Aih3

Amelogenesis Imperfecta 3, Hypoplastic Type, Formerly

Aih3, Formerly

Amelogenesis Imperfecta, Type Ie, X-Linked 2

Amelogenesis Imperfecta Type Ie X-Linked 2

Amelogenesis Imperfecta 3 Hypoplastic Type

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta 3, Hypoplastic Type

Amelogenesis Imperfecta-3, Hypoplastic Type

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Type Iv

AI4

Aihht

Amelogenesis Imperfecta Type 4

Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism

Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism

Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism

Amelogenesis Imperfecta 4

Ait

Amelogenesis Imperfecta 2 Hypocalcification Type

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iv

Amelogenesis Imperfecta With Taurodontism
Dentine Erosion
Dental Fluorosis

Mottled Teeth

Intrinsic Enamel Discolouration Of Fluorosis

Mottling Of Enamel

Fluorosis, Dental

Dental Fluorosis, Acquired
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Enamel Caries

Primary Dental Caries

Dental Caries Limited To Enamel

Simple Dental Cavity
Tooth Erosion

Generalized Erosion

Localized Erosion

Generalized Erosions

Erosion, Localized
Teeth Hard Tissue Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15268 TUFT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TUFT1 MGD MGI:109572
Felis catus TUFT1 VGNC VGNC:66709
Rattus norvegicus TUFT1 RGD RGD:1310373
Bos taurus TUFT1 VGNC VGNC:36518
Macaca mulatta TUFT1 VGNC VGNC:78675
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