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  2. BAG1 - BAG cochaperone 1 Gene

BAG1 - BAG cochaperone 1 Gene

中文名称:BAG 辅伴侣 1

种属: Homo sapiens

同用名: HAP; BAG-1; RAP46

基因 ID: 573 | 基因类型: protein coding

关于 BAG1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,252,471-33,264,708 (from NCBI)

This gene has 11 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues.

功能概要

致癌基因 BCL2 是一种膜蛋白,可阻断导致细胞凋亡或程序性细胞死亡的途径中的一个步骤。该基因编码的蛋白质与 BCL2 结合,被称为 BCL2 相关致死基因。它增强了 BCL2 的抗细胞凋亡作用,代表了生长因子受体与抗细胞凋亡机制之间的联系。通过使用非 AUG (CUG) 起始密码子和三个替代的下游 AUG 起始密码子,该 mRNA 编码多种蛋白质亚型。已在 X 染色体上定义了一个相关的假基因。[RefSeq 提供,2010 年 2 月]

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to Apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

BAG1 基因产物(4)

mRNA Protein Name
NM_001172415.2 NP_001165886.1 BAG family molecular chaperone regulator 1 isoform BAG-1S
NM_001349286.2 NP_001336215.1 BAG family molecular chaperone regulator 1 isoform BAG-1M
NM_001349299.2 NP_001336228.1 BAG family molecular chaperone regulator 1 isoform BAG1
NM_004323.6 NP_004314.6 BAG family molecular chaperone regulator 1 isoform BAG-1L
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
24318877 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9305631 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16207813 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chaperone cofactor-dependent protein refolding IDA
IDA: 通过直接分析推断
12853476 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9679980 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BAG1 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (170 - 220)

BAG

BAG: BAG domain (250 - 325)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

BAG family molecular chaperone regulator 1

BCL2 associated athanogene 1

BAG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BAG1 Q99933 HSPA8 Homo sapiens Q96IS6
Validated Y2H
25416956
Intra BAG1 Q99933 HSPA8 Homo sapiens Q96IS6
Y2H Array
25416956
Intra BAG1 Q99933 MLF2 Homo sapiens Q15773
Anti Tag CoIP
25036637
Intra BAG1 Q99933 MLF2 Homo sapiens Q15773
Lumier
25036637
Intra BAG1 Q99933 HSPA8 Homo sapiens P11142
Validated Y2H
26871637
Intra BAG1 Q99933 HSPA8 Homo sapiens P11142
Y2H Prey Pooling
26871637
Intra BAG1 Q99933 HSPA8 Homo sapiens P11142
SPR
19800331
Intra BAG1 Q99933 HSPA8 Homo sapiens P11142
Y2H Array
26871637
Intra BAG1 Q99933 STUB1 Homo sapiens Q9UNE7
Anti Tag CoIP
25036637
Intra BAG1 Q99933 PSMD2 Homo sapiens Q13200
Lumier
25036637
Intra BAG1 Q99933 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
33961781
Intra BAG1 Q99933 PSMD2 Homo sapiens Q13200
Y2H Array
25416956
Intra BAG1 Q99933 PSMD2 Homo sapiens Q13200
Y2H Array
32296183
Intra BAG1 Q99933 PSMD2 Homo sapiens Q13200
Y2H Prey Pooling
25416956
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Y2H Array
31515488
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Validated Y2H
26871637
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
26871637
Intra BAG1 Q99933 TRIM27 Homo sapiens P14373
Y2H Array
26871637
Intra BAG1 Q99933 q96be0_human Homo sapiens Q96BE0
Lumier
25036637
Intra BAG1 Q99933 q53fc7_human Homo sapiens Q53FC7
Lumier
25036637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BAG1 VGNC VGNC:84875
Felis catus BAG1 VGNC VGNC:69043
Bos taurus BAG1 VGNC VGNC:26405
Canis familiaris BAG1 VGNC VGNC:38363
Mus musculus BAG1 MGD MGI:108047
Rattus norvegicus BAG1 RGD RGD:1305203