TPRKB - TP53RK binding protein Gene

中文名称：TP53RK 结合蛋白

种属: Homo sapiens

同用名: CGI121; GAMOS5; CGI-121

基因 ID: 51002 | 基因类型: protein coding

关于 TPRKB

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,729,873-73,737,345 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 8.1), colon (RPKM 6.1) and 25 other tissues.

功能概要

启用蛋白激酶结合活性。参与 tRNA 苏氨酰氨基甲酰腺苷修饰。位于细胞质和细胞核中。 EKC/KEOPS 复合体的一部分。涉及 Galloway-Mowat 综合征 5。[由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Apr 2022]

TPRKB 基因产物(8)

mRNA	Protein	Name
NM_001330386.2	NP_001317315.1	EKC/KEOPS complex subunit TPRKB isoform a
NM_001330387.2	NP_001317316.1	EKC/KEOPS complex subunit TPRKB isoform a
NM_001330388.2	NP_001317317.1	EKC/KEOPS complex subunit TPRKB isoform b
NM_001330389.2	NP_001317318.1	EKC/KEOPS complex subunit TPRKB isoform b
NM_001330390.2	NP_001317319.1	EKC/KEOPS complex subunit TPRKB isoform c
NM_001330391.2	NP_001317320.1	EKC/KEOPS complex subunit TPRKB isoform d
NM_001330392.2	NP_001317321.1	EKC/KEOPS complex subunit TPRKB isoform d
NM_016058.5	NP_057142.1	EKC/KEOPS complex subunit TPRKB isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12659830	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in tRNA threonylcarbamoyladenosine modification	IDA IDA: 通过直接分析推断	28805828	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of EKC/KEOPS complex	IDA IDA: 通过直接分析推断	27903914	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	28805828	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12659830	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12659830	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPRKB 蛋白结构

CGI-121

0
100
175 a.a.

蛋白主名

其他名称

EKC/KEOPS complex subunit TPRKB

PRPK (p53-related protein kinase)-binding protein

TPRKB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TPRKB	Q9Y3C4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	TPRKB	Q9Y3C4	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	TPRKB	Q9Y3C4	TP53RK	Homo sapiens	Q96S44	Y2H Array	31515488
Intra	TPRKB	Q9Y3C4	TP53RK	Homo sapiens	Q96S44	Y2H Fragment Pooling	23414517

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Galloway-Mowat Syndrome 5

GAMOS5

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Galloway-Mowat Syndrome 1

Galloway Syndrome	Nephrosis-Neuronal Dysmigration Syndrome
Nephrosis-Microcephaly Syndrome	Camos
Scar5	GAMOS1
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Microcephaly, Hiatal Hernia And Nephrotic Syndrome
Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities	Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly
Scar5, Formerly	Spinocerebellar Ataxia Autosomal Recessive 5
Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities	Camos Syndrome
Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome	Galloway-Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 5	Galloway Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 5

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Galloway-Mowat Syndrome 2

Bladder Calculus

Urinary Bladder Calculi	Urinary Bladder Stone
Bladder Calculi	Bladder Stone
Urinary Bladder Calculus	Vesical Calculi
Vesical Calculus	Vesicolithiasis
Cystolithiasis	Cystic Calculi
Cystic Calculus

Lower Urinary Tract Calculus

Calculus Of Lower Urinary Tract

Cerebellar Hypoplasia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Polymicrogyria

Pmg

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14949	TPRKB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TPRKB	VGNC	VGNC:79426
Rattus norvegicus	TPRKB	RGD	RGD:1309786
Canis familiaris	TPRKB	VGNC	VGNC:47754
Mus musculus	TPRKB	MGD	MGI:1917036
Bos taurus	TPRKB	VGNC	VGNC:36263

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPRKB - TP53RK binding protein Gene

关于 TPRKB

功能概要

TPRKB 基因产物(8)

TPRKB 蛋白结构

TPRKB 蛋白互作信息

关联疾病

直系同源

热门区域

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TPRKB - TP53RK binding protein Gene

关于 TPRKB

功能概要

TPRKB 基因产物(8)

TPRKB 蛋白结构

TPRKB 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z