1. Gene
  2. TP53RK - TP53 regulating kinase Gene

TP53RK - TP53 regulating kinase Gene

中文名称:TP53 调节激酶

种属: Homo sapiens

同用名: PRPK; BUD32; TPRKB; GAMOS4; Nori-2; Nori-2p; dJ101A2; C20orf64

基因 ID: 112858 | 基因类型: protein coding

关于 TP53RK

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,684,365-46,689,444 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 5.4), thyroid (RPKM 5.0) and 25 other tissues.

功能概要

启用 p53 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与蛋白质磷酸化。位于细胞质和细胞核中。 EKC/KEOPS 复合体的一部分。涉及 Galloway-Mowat 综合征 4。[由基因组资源联盟提供,2022 年 4 月]

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Apr 2022]

TP53RK 基因产物(1)

mRNA Protein Name
NM_033550.4 NP_291028.3 EKC/KEOPS complex subunit TP53RK
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables p53 binding IDA
IDA: 通过直接分析推断
11546806 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11546806 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11546806 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11546806 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of EKC/KEOPS complex IDA
IDA: 通过直接分析推断
27903914 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
28805828 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11546806 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TP53RK 蛋白结构

Kdo

Kdo: Lipopolysaccharide kinase (Kdo/WaaP) family (72 - 225)

  • 0
  • 100
  • 200
  • 253 a.a.
蛋白主名 其他名称

EKC/KEOPS complex subunit TP53RK

atypical serine/threonine protein kinase TP53RK

TP53RK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TP53RK Q96S44 OSGEP Homo sapiens Q9NPF4
Anti Tag CoIP
28514442
Intra TP53RK Q96S44 OSGEP Homo sapiens Q9NPF4
Pull Down
32707033
Intra TP53RK Q96S44 OSGEP Homo sapiens Q9NPF4
Anti Tag CoIP
33961781
Intra TP53RK Q96S44 OSGEP Homo sapiens Q9NPF4
TAP
23455922
Intra TP53RK Q96S44 OSGEP Homo sapiens Q9NPF4
Y2H Fragment Pooling
23414517
Intra TP53RK Q96S44 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra TP53RK Q96S44 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra TP53RK Q96S44 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra TP53RK Q96S44 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra TP53RK Q96S44 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra TP53RK Q96S44 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra TP53RK Q96S44 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra TP53RK Q96S44 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra TP53RK Q96S44 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra TP53RK Q96S44 TPRKB Homo sapiens Q9Y3C4
Pull Down
32707033
Intra TP53RK Q96S44 TPRKB Homo sapiens Q9Y3C4
Anti Tag CoIP
33961781
Intra TP53RK Q96S44 TPRKB Homo sapiens Q9Y3C4
Y2H Pooling
16189514
Intra TP53RK Q96S44 TPRKB Homo sapiens Q9Y3C4
TAP
23455922
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Galloway-Mowat Syndrome 4

GAMOS4

Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis

Galloway-Mowat Syndrome 1

Galloway Syndrome

Nephrosis-Neuronal Dysmigration Syndrome

Nephrosis-Microcephaly Syndrome

Camos

Scar5

GAMOS1

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Microcephaly, Hiatal Hernia And Nephrotic Syndrome

Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities

Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly

Scar5, Formerly

Spinocerebellar Ataxia Autosomal Recessive 5

Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities

Camos Syndrome

Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome

Galloway-Mowat Syndrome

Spinocerebellar Ataxia, Autosomal Recessive, 5

Galloway Mowat Syndrome

Spinocerebellar Ataxia, Autosomal Recessive 5

Galloway-Mowat Syndrome 2
Bladder Calculus

Urinary Bladder Calculi

Urinary Bladder Stone

Bladder Calculi

Bladder Stone

Urinary Bladder Calculus

Vesical Calculi

Vesical Calculus

Vesicolithiasis

Cystolithiasis

Cystic Calculi

Cystic Calculus

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Lower Urinary Tract Calculus

Calculus Of Lower Urinary Tract

Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria

Polymicrogyria

Pmg

Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TP53RK VGNC VGNC:108069
Rattus norvegicus TP53RK RGD RGD:1591394
Mus musculus TP53RK MGD MGI:1918294
Bos taurus TP53RK VGNC VGNC:36238
Canis familiaris TP53RK VGNC VGNC:47727
Others TP53RK NCBI