2. Gene
  3. FOXB1 - forkhead box B1 Gene

FOXB1 - forkhead box B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 B1

种属: Homo sapiens

同用名: FKH5; HFKH-5

基因 ID: 27023 | 基因类型: protein coding

关于 FOXB1

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:60,004,311-60,007,444 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues and 42 paralogues. Low expression observed in reference dataset.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与多个过程，包括乳腺发育；神经系统发育；和视觉学习。预测作用于脊髓发育的上游或内部；丘脑发育；和泌尿生殖系统发育。预测位于核内。预测是染色质的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to act upstream of or within spinal cord development; thalamus development; and urogenital system development. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

FOXB1 基因产物(1)

mRNA Protein Name
NM_012182.3 NP_036314.2 forkhead box protein B1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXB1 蛋白结构

Forkhead

Forkhead: Forkhead domain (13 - 108)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

forkhead box protein B1

transcription factor FKH-5

FOXB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXB1 Q99853 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
种属内
FOXB1 Q99853 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
FOXB1 Q99853 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
种属内
FOXB1 Q99853 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wernicke-Korsakoff Syndrome

Korsakoff Syndrome

Transketolase Defect

Korsakoff'S Syndrome

Alcohol-Induced Encephalopathy

Korsakoff'S Psychosis

Korsakov Psychosis

Korsakov'S Psychosis

Alcohol Induced Encephalopathy

Korsakoff Disease

Korsakoff Psychosis
Thiamine Deficiency Disease
Septooptic Dysplasia

Septo-Optic Dysplasia

De Morsier Syndrome

Growth Hormone Deficiency With Pituitary Anomalies

SOD

Pituitary Hormone Deficiency, Combined, 5

Septo-Optic Dysplasia Spectrum

Septo-Optic Dysplasia With Growth Hormone Deficiency

Pituitary Hormone Deficiency, Combined 5

Hypopituitarism And Septooptic 'Dysplasia'

GHDPA

CPHD5

Dysplasia, Septo-Optic

Kallmann Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05039 FOXB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FOXB1 VGNC VGNC:29080
Macaca mulatta FOXB1 VGNC VGNC:72692
Felis catus FOXB1 VGNC VGNC:62331
Rattus norvegicus FOXB1 RGD RGD:1305217
Mus musculus FOXB1 MGD MGI:1927549
Canis familiaris FOXB1 VGNC VGNC:40946
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