STK25 - serine/threonine kinase 25 Gene

中文名称：丝氨酸/苏氨酸激酶 25

种属: Homo sapiens

同用名: SOK1; YSK1

基因 ID: 10494 | 基因类型: protein coding

关于 STK25

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,492,670-241,509,572 (from NCBI)

This gene has 35 transcripts (splice variants), 208 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues.

功能概要

该基因编码不育 20 激酶超家族的生发中心激酶 III (GCK III) 亚家族的成员。编码的酶在丝氨酸-苏氨酸肝激酶 B1 (LKB1) 信号通路中起作用，以调节高尔基体的神经元极化和形态。该蛋白质响应化学性缺氧从高尔基体转移到细胞核，并在调节细胞死亡中发挥作用。与该基因相关的假基因位于 18 号染色体上。已观察到该基因的多个选择性剪接转录物变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded Enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

STK25 基因产物(9)

mRNA	Protein	Name
NM_001271977.2	NP_001258906.1	serine/threonine-protein kinase 25 isoform 1
NM_001271978.2	NP_001258907.1	serine/threonine-protein kinase 25 isoform 1
NM_001271979.2	NP_001258908.1	serine/threonine-protein kinase 25 isoform 2
NM_001271980.2	NP_001258909.1	serine/threonine-protein kinase 25 isoform 2
NM_001282305.1	NP_001269234.1	serine/threonine-protein kinase 25 isoform 3
NM_001282306.2	NP_001269235.1	serine/threonine-protein kinase 25 isoform 4
NM_001282307.2	NP_001269236.1	serine/threonine-protein kinase 25 isoform 3
NM_001282308.2	NP_001269237.1	serine/threonine-protein kinase 25 isoform 3
NM_006374.5	NP_006365.2	serine/threonine-protein kinase 25 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15037601	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	15037601	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi localization	IDA IDA: 通过直接分析推断	15037601	GOA
involved in Golgi reassembly	IMP IMP: 通过突变表型推断	20332113	GOA
involved in cellular response to oxidative stress	IDA IDA: 通过直接分析推断	22291017	GOA
involved in establishment of Golgi localization	IMP IMP: 通过突变表型推断	20332113	GOA
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI IGI: 通过遗传相互作用推断	22652780	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	22652780	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	17657516	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	17657516	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FAR/SIN/STRIPAK complex	IDA IDA: 通过直接分析推断	18782753	GOA
colocalizes with Golgi apparatus	IDA IDA: 通过直接分析推断	22652780	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	22652780	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STK25 蛋白结构

Pkinase

0
100
200
300
400
426 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase 25

Ste20, yeast homolog

STK25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STK25	O00506	STRN	Homo sapiens	O43815	Anti Tag CoIP	28514442
种属内	STK25	O00506	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
种属内	STK25	O00506	STRN	Homo sapiens	O43815	Anti Tag CoIP	35271311
种属内	STK25	O00506	STRN	Homo sapiens	O43815	TAP	23455922
种属内	STK25	O00506	STRN	Homo sapiens	O43815	Pull Down	32707033
种属内	STK25	O00506	STRN	Homo sapiens	O43815	Anti Tag CoIP	33961781
种属内	STK25	O00506	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	33961781
种属内	STK25	O00506	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	28514442
种属内	STK25	O00506	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	21423148
种属内	STK25	O00506	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
种属内	STK25	O00506	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	TAP	23455922
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	26871637
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Pull Down	32707033
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Y2H Array	26871637
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Validated Y2H	26871637
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Y2H	15037601
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Anti Tag CoIP	28514442
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
种属内	STK25	O00506	GOLGA2	Homo sapiens	Q08379	Anti Tag CoIP	33961781
种属内	STK25	O00506	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
种属内	STK25	O00506	TRIM27	Homo sapiens	P14373	Validated Y2H	26871637
种属内	STK25	O00506	TRIM27	Homo sapiens	P14373	Y2H Array	26871637
种属内	STK25	O00506	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	26871637
种属内	STK25	O00506	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
种属内	STK25	O00506	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	TAP	23455922
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	Y2H Prey Pooling	25416956
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	Protein Kinase Assay	17657516
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	Y2H Array	25416956
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	Y2H Pooling	16189514
种属内	STK25	O00506	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	18782753
种属内	STK25	O00506	CCNDBP1	Homo sapiens	O95273	Validated Y2H	32296183
种属内	STK25	O00506	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
种属内	STK25	O00506	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
种属内	STK25	O00506	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
种属内	STK25	O00506	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
种属间	STK25	O00506	Golga2	Rattus norvegicus	Q62839	Y2H	15037601
种属间	STK25	O00506	Golga2	Rattus norvegicus	Q62839	Pull Down	15037601

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Pseudopseudohypoparathyroidism

PPHP	Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance
Normocalcemic Pseudohypoparathyroidism	Aho-Pphp Syndrome
Albright Hereditary Osteodystrophy-Pphp Syndrome	Pseudohypoparathyroidism

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13928	STK25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	STK25	VGNC	VGNC:35391
Canis familiaris	STK25	VGNC	VGNC:46909
Rattus norvegicus	STK25	RGD	RGD:727809
Mus musculus	STK25	MGD	MGI:1891699
Macaca mulatta	STK25	VGNC	VGNC:81584
Felis catus	STK25	VGNC	VGNC:80368
Others	STK25	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STK25 - serine/threonine kinase 25 Gene

关于 STK25

功能概要

STK25 基因产物(9)

STK25 蛋白结构

STK25 蛋白互作信息

关联疾病

直系同源

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STK25 - serine/threonine kinase 25 Gene

关于 STK25

功能概要

STK25 基因产物(9)

STK25 蛋白结构

STK25 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z