STRN - striatin Gene

中文名称：纹状蛋白

种属: Homo sapiens

同用名: SG2NA; STRN1; PPP2R6A

基因 ID: 6801 | 基因类型: protein coding

关于 STRN

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,837,698-36,966,536 (from NCBI)

This gene has 3 transcripts (splice variants), 271 orthologues, 2 paralogues and is associated with 73 phenotypes. Ubiquitous expression in esophagus (RPKM 6.7), brain (RPKM 5.1) and 25 other tissues.

功能概要

启用犰狳重复域绑定活动；雌激素受体结合活性；和蛋白磷酸酶 2A 结合活性。参与 Wnt 信号通路和细胞群增殖的负调控。位于双细胞紧密连接处。 FAR/SIN/STRIPAK 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables armadillo repeat domain binding activity; Estrogen Receptor binding activity; and protein Phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN 基因产物(1)

mRNA	Protein	Name
NM_003162.4	NP_003153.2	striatin

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables armadillo repeat domain binding	IPI IPI: 通过物理相互作用推断	18502210	GOA
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	15569929	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17540176	GOA
enables protein phosphatase 2A binding	IDA IDA: 通过直接分析推断	18782753	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	18782753	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Wnt signaling pathway	IMP IMP: 通过突变表型推断	18502210	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	18502210	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FAR/SIN/STRIPAK complex	IDA IDA: 通过直接分析推断	18782753	GOA
located in bicellular tight junction	IDA IDA: 通过直接分析推断	18502210	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STRN 蛋白结构

Striatin

WD40

0
200
400
600
780 a.a.

蛋白主名

其他名称

striatin

protein phosphatase 2 regulatory subunit B'''alpha

STRN 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	18782753
种属内	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	33961781
种属内	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	26496610
种属内	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Bait CoIP	18782753
种属内	STRN	O43815	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	24366813
种属内	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	24366813
种属内	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	26496610
种属内	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	33961781
种属内	STRN	O43815	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
种属内	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	33961781
种属内	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
种属内	STRN	O43815	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	18782753
种属内	STRN	O43815	TNKS2	Homo sapiens	Q9H2K2	FPS	22153077
种属内	STRN	O43815	STK25	Homo sapiens	O00506	Anti Tag CoIP	18782753
种属内	STRN	O43815	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781
种属内	STRN	O43815	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	18782753
种属内	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	24366813
种属内	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	18782753
种属内	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	33961781
种属内	STRN	O43815	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	26496610
种属内	STRN	O43815	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	25416956
种属内	STRN	O43815	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	25416956
种属内	STRN	O43815	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	18782753
种属内	STRN	O43815	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	33961781
种属内	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	26496610
种属内	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	18782753
种属内	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	33961781
种属内	STRN	O43815	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	24366813
种属内	STRN	O43815	TRAF3IP3	Homo sapiens	Q9Y228	Anti Tag CoIP	18782753

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Metanephric Adenoma

Renal Adenoma

Renal Cell Adenoma

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13966	STRN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13967	STRN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13968	STRN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	STRN	VGNC	VGNC:78039
Rattus norvegicus	STRN	RGD	RGD:3782
Bos taurus	STRN	VGNC	VGNC:35424
Canis familiaris	STRN	VGNC	VGNC:46945
Mus musculus	STRN	MGD	MGI:1333757
Felis catus	STRN	VGNC	VGNC:81230

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STRN - striatin Gene

关于 STRN

功能概要

STRN 基因产物(1)

STRN 蛋白结构

STRN 蛋白互作信息

关联疾病

直系同源

热门区域

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STRN - striatin Gene

关于 STRN

功能概要

STRN 基因产物(1)

STRN 蛋白结构

STRN 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z