1. Gene
  2. STK24 - serine/threonine kinase 24 Gene

STK24 - serine/threonine kinase 24 Gene

中文名称:丝氨酸/苏氨酸激酶 24

种属: Homo sapiens

同用名: MST3; STK3; MST3B; STE20; HEL-S-95

基因 ID: 8428 | 基因类型: protein coding

关于 STK24

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:98,445,185-98,577,107 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues.

功能概要

该基因编码一种丝氨酸/苏氨酸蛋白激酶,它在有丝分裂原活化蛋白激酶 (MAPK) 信号传导的上游发挥作用。编码的蛋白质被半胱天冬酶切割成两条链; N 端片段 (MST3/N) 易位至细胞核并促进程序性细胞死亡。该基因在 X 染色体上有一个假基因。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 11 月]

This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

STK24 基因产物(3)

mRNA Protein Name
NM_001032296.4 NP_001027467.2 serine/threonine-protein kinase 24 isoform b precursor
NM_001286649.2 NP_001273578.1 serine/threonine-protein kinase 24 isoform c precursor
NM_003576.5 NP_003567.2 serine/threonine-protein kinase 24 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
16314523 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
22291017 GOA
involved in cellular response to starvation IMP
IMP: 通过突变表型推断
27807006 GOA
involved in execution phase of apoptosis IMP
IMP: 通过突变表型推断
12107159 GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
19604147 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
17046825 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
17046825 GOA
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
27807006 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
19604147 GOA
involved in regulation of axon regeneration IMP
IMP: 通过突变表型推断
19855390 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FAR/SIN/STRIPAK complex IDA
IDA: 通过直接分析推断
18782753 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12107159 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12107159 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STK24 蛋白结构

Pkinase

Pkinase: Protein kinase domain (36 - 286)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase 24

STE20-like kinase 3

STK24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STK24 Q9Y6E0 STRN Homo sapiens O43815 17353931
种属内
STK24 Q9Y6E0 STRN Homo sapiens O43815
TAP
23455922
种属内
STK24 Q9Y6E0 STRN Homo sapiens O43815 32707033
种属内
STK24 Q9Y6E0 STRN Homo sapiens O43815 35271311
种属内
STK24 Q9Y6E0 STRN Homo sapiens O43815 18782753
种属内
STK24 Q9Y6E0 STRIP1 Homo sapiens Q5VSL9 35271311
种属内
STK24 Q9Y6E0 STRIP1 Homo sapiens Q5VSL9 18782753
种属内
STK24 Q9Y6E0 STRIP1 Homo sapiens Q5VSL9 32707033
种属内
STK24 Q9Y6E0 CTTNBP2NL Homo sapiens Q9P2B4 32707033
种属内
STK24 Q9Y6E0 CTTNBP2NL Homo sapiens Q9P2B4 18782753
种属内
STK24 Q9Y6E0 CTTNBP2NL Homo sapiens Q9P2B4
TAP
23455922
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 17353931
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 31515488
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8
Y2H
17657516
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8
TAP
23455922
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 32707033
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 35271311
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8
Y2H
21516116
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 16189514
种属内
STK24 Q9Y6E0 PDCD10 Homo sapiens Q9BUL8 18782753
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous

Inflammatory Bowel Disease 14

IBD14

Inflammatory Bowel Disease 14, Susceptibility To

Bowel Disease, Inflammatory, Type 14

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3

Arthrogryposis, Distal, Type 3

Gordon Syndrome

DA3

Distal Arthrogryposis Type 3

Arthrogryposis Multiplex Congenita, Distal, Type Iia

Camptodactyly, Cleft Palate, And Clubfoot

Camptodactyly-Cleft Palate-Clubfoot Syndrome

Distal Arthrogryposis Multiplex Congenita Type Iia

Arthrogryposis Distal Type 3

Distal Arthrogryposis Type Iia

Arthrogryposis, Distal, 3

Pseudohypoaldosteronism, Type Ii

Gitelman Syndrome

Familial Hypokalemia-Hypomagnesemia

Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria

Potassium And Magnesium Depletion

GTLMNS

Gitelman'S Syndrome

Gs

Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria

Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria

Bartter Syndrome Gitelman Variant

Bartter Syndrome Hypocalciuric Variant

Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria

Pseudohypoaldosteronism
Agenesis Of The Corpus Callosum With Peripheral Neuropathy

Andermann Syndrome

Charlevoix Disease

ACCPN

Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum

Corpus Callosum, Agenesis Of, With Neuronopathy

Corpus Callosum Agenesis-Neuronopathy Syndrome

Agenesis Of Corpus Callosum With Neuronopathy

Agenesis Of Corpus Callosum With Peripheral Neuropathy

Agenesis Of Corpus Callosum With Polyneuropathy

Corpus Callosum Agenesis Neuronopathy

Hmsn/Acc

Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum

Agenesis Of The Corpus Callosum, With Peripheral Neuropathy

Andermann'S Syndrome

Agenesis, Corpus Callosum, With Peripheral Neuropathy

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome

CCMS

Rib Gap Defects With Micrognathia

Ccm Syndrome

Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus STK24 MGD MGI:2385007
Macaca mulatta STK24 VGNC VGNC:81583
Felis catus STK24 VGNC VGNC:97647
Bos taurus STK24 VGNC VGNC:35390
Rattus norvegicus STK24 RGD RGD:1561742
Canis familiaris STK24 VGNC VGNC:49657
Others STK24 NCBI