PLEKHN1 - pleckstrin homology domain containing N1 Gene

中文名称：含 pleckstrin 同源结构域 N1

种属: Homo sapiens

同用名: CLPABP

基因 ID: 84069 | 基因类型: protein coding

关于 PLEKHN1

This gene has 5 transcripts (splice variants), 126 orthologues and 22 paralogues. Biased expression in skin (RPKM 9.8), esophagus (RPKM 3.7) and 3 other tissues.

功能概要

启用磷脂结合活性。参与 3'-UTR 介导的 mRNA 去稳定化；凋亡过程的正调控；和对缺氧的反应。位于细胞骨架和线粒体膜上。 [由基因组资源联盟提供，2022 年 4 月]

Enables phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Located in Cytoskeleton and mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHN1 基因产物(4)

mRNA	Protein	Name
NM_001160184.2	NP_001153656.1	pleckstrin homology domain-containing family N member 1 isoform b
NM_001367552.1	NP_001354481.1	pleckstrin homology domain-containing family N member 1 isoform c
NM_001410697.1	NP_001397626.1	pleckstrin homology domain-containing family N member 1 isoform d
NM_032129.3	NP_115505.2	pleckstrin homology domain-containing family N member 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cardiolipin binding	IDA IDA: 通过直接分析推断	18191643	GOA
enables phosphatidic acid binding	IDA IDA: 通过直接分析推断	18191643	GOA
enables phosphatidylinositol phosphate binding	IDA IDA: 通过直接分析推断	18191643	GOA
enables phosphatidylserine binding	IDA IDA: 通过直接分析推断	18191643	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18191643	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: 通过直接分析推断	29180010	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	29531808	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	29531808	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoskeleton	IDA IDA: 通过直接分析推断	18191643	GOA
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	18191643	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	27616329	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

pleckstrin homology domain-containing family N member 1

PH domain-containing family N member 1

PLEKHN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PLEKHN1	Q494U1	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
Intra	PLEKHN1	Q494U1	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	PLEKHN1	Q494U1	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	PLEKHN1	Q494U1	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	PLEKHN1	Q494U1	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	PLEKHN1	Q494U1	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	PLEKHN1	Q494U1	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	PLEKHN1	Q494U1	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	PLEKHN1	Q494U1	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	PLEKHN1	Q494U1	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	PLEKHN1	Q494U1	LPXN	Homo sapiens	O60711	Validated Y2H	25416956
Intra	PLEKHN1	Q494U1	RFX6	Homo sapiens	Q8HWS3	Y2H Prey Pooling	25416956
Intra	PLEKHN1	Q494U1	RFX6	Homo sapiens	Q8HWS3	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myasthenic Syndrome, Congenital, 8

Congenital Myasthenic Syndrome 8	CMS8
Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects	Cmsppd
Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects	Congenital Myasthenic Syndrome Due To Agrin Deficiency
Myasthenic Syndrome, Congenital, Due To Agrin Deficiency	Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects
Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects

Neuropathy, Hereditary Sensory And Autonomic, Type Vii

Hereditary Sensory And Autonomic Neuropathy Type 7	HSAN7
Hereditary Sensory And Autonomic Neuropathy Type Vii	Hsan Vii
Cip With Hyperhidrosis And Gastrointestinal Dysfunction	Congenital Insensitivity To Pain With Hyperhidrosis And Gastrointestinal Dysfunction
Hsan With Hyperhidrosis And Gastrointestinal Dysfunction	Hereditary Sensory And Autonomic Neuropathy With Hyperhidrosis And Gastrointestinal Dysfunction
Insensitivity To Pain, Congenital, With Gastrointestinal Dysfunction And Hyperhidrosis	Neuropathy, Hereditary Sensory And Autonomic, 7
Congenital Insensitivity To Pain With Gastrointestinal Dysfunction And Hyperhidrosis	Neuropathy, Sensory And Autonomic, Hereditary, Type Vii

Neuropathy, Hereditary Sensory And Autonomic, Type Viii

HSAN8	Hsan Viii
Hereditary Sensory And Autonomic Neuropathy Type 8	Hereditary Sensory And Autonomic Neuropathy Type Viii
Neuropathy, Hereditary Sensory And Autonomic, 8	Neuropathy, Sensory And Autonomic, Hereditary, Type Viii

Neuropathy, Hereditary Sensory And Autonomic, Type V

HSAN5	Hereditary Sensory And Autonomic Neuropathy Type V
Hsan V	Hereditary Sensory And Autonomic Neuropathy Type 5
Congenital Insensitivity To Pain	Congenital Sensory Neuropathy With Selective Loss Of Small Myelinated Fibers
Hsan Type V	Insensitivity To Pain, Congenital
Hereditary Sensory And Autonomic Neuropathy, Type 5	Congenital Insensitivity To Pain And Thermal Analgesia
Neuropathy, Hereditary Sensory And Autonomic, 5	Hereditary Sensory Neuropathy Type V
Hsn V	Pain Insensitivity, Congenital
Neuropathy, Sensory And Autonomic, Hereditary, Type V	Hereditary Sensory Autonomic Neuropathy, Type 5
Hsan5 - [Hereditary Sensory And Autonomic Neuropathy Type 5]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10699	PLEKHN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PLEKHN1	VGNC	VGNC:76108
Felis catus	PLEKHN1	VGNC	VGNC:64238
Bos taurus	PLEKHN1	VGNC	VGNC:33025
Mus musculus	PLEKHN1	MGD	MGI:2387630
Rattus norvegicus	PLEKHN1	RGD	RGD:1311019
Canis familiaris	PLEKHN1	VGNC	VGNC:44686

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PLEKHN1 - pleckstrin homology domain containing N1 Gene

关于 PLEKHN1

功能概要

PLEKHN1 基因产物(4)

PLEKHN1 蛋白互作信息

关联疾病

直系同源

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PLEKHN1 - pleckstrin homology domain containing N1 Gene

关于 PLEKHN1

功能概要

PLEKHN1 基因产物(4)

PLEKHN1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z