LASP1 - LIM and SH3 protein 1 Gene

中文名称：LIM 和 SH3 蛋白 1

种属: Homo sapiens

同用名: MLN50; Lasp-1

基因 ID: 3927 | 基因类型: protein coding

关于 LASP1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,870,058-38,921,770 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 4 paralogues and is associated with 52 phenotypes. Ubiquitous expression in small intestine (RPKM 79.0), duodenum (RPKM 59.7) and 25 other tissues.

功能概要

该基因编码 LIM 蛋白亚家族的成员，其特征是 LIM 基序和 Src 同源区 3 的结构域，也是肌动蛋白结合蛋白 nebulin 家族的成员。编码的蛋白质是一种依赖于 cAMP 和 cGMP 的信号转导蛋白，并与细胞膜延伸处的肌动蛋白细胞骨架结合。编码的蛋白质与转移性乳腺癌、B 细胞淋巴瘤等造血肿瘤和结直肠癌有关。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin Cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast Cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal Cancer. [provided by RefSeq, Oct 2012]

LASP1 基因产物(2)

mRNA	Protein	Name
NM_001271608.2	NP_001258537.1	LIM and SH3 domain protein 1 isoform b
NM_006148.4	NP_006139.1	LIM and SH3 domain protein 1 isoform a

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	25468996	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LASP1 蛋白结构

LIM

Nebulin

SH3_9

0
100
200
261 a.a.

蛋白主名

其他名称

LIM and SH3 domain protein 1

metastatic lymph node gene 50 protein

LASP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LASP1	Q14847	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	Far-WB	22665060
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	PLA	22665060
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	Pull Down	22665060
Intra	LASP1	Q14847	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Y2H	21516116
Intra	LASP1	Q14847	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Array	31515488
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Array	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	SH2D2A	Homo sapiens	Q9NP31	Lumier	25814554
Intra	LASP1	Q14847	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	LASP1	Q14847	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Array	25416956
Intra	LASP1	Q14847	ZC2HC1A	Homo sapiens	Q96GY0	Validated Y2H	25416956
Intra	LASP1	Q14847	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	LASP1	Q14847	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
Intra	LASP1	Q14847	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904
Intra	LASP1	Q14847	SEPTIN3	Homo sapiens	Q9UH03	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Validated Y2H	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Y2H Array	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	LASP1	Q14847	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Validated Y2H	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07535	LASP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LASP1	MGD	MGI:109656
Rattus norvegicus	LASP1	RGD	RGD:68408
Macaca mulatta	LASP1	VGNC	VGNC:74237
Bos taurus	LASP1	VGNC	VGNC:30798
Felis catus	LASP1	VGNC	VGNC:99182
Canis familiaris	LASP1	VGNC	VGNC:42595
Others	LASP1	NCBI

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