2. Gene
  3. ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho 鸟嘌呤核苷酸交换因子 15

种属: Homo sapiens

同用名: E5; ARGEF15; Ephexin5; Vsm-RhoGEF

基因 ID: 22899 | 基因类型: protein coding

关于 ARHGEF15

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,310,241-8,322,511 (from NCBI)

This gene has 9 transcripts (splice variants), 213 orthologues and 6 paralogues. Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues.

功能概要

Rho GTP 酶在许多细胞过程中起着重要作用，这些过程由通过 G 蛋白偶联受体起作用的细胞外刺激物启动。该基因编码的蛋白质可作为 RhoA 的特定鸟嘌呤核苷酸交换因子。它还与血管平滑肌细胞中的肝配蛋白 A4 相互作用。已为该基因发现了编码相同蛋白质的两个可变剪接转录物变体。[RefSeq 提供，2010 年 8 月]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

ARHGEF15 基因产物(2)

mRNA Protein Name
NM_025014.2 NP_079290.1 rho guanine nucleotide exchange factor 15
NM_173728.4 NP_776089.2 rho guanine nucleotide exchange factor 15
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
12775584 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12775584 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of catalytic activity IDA
IDA: 通过直接分析推断
12775584 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGEF15 蛋白结构

RhoGEF

RhoGEF: RhoGEF domain (422 - 598)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
蛋白主名 其他名称

rho guanine nucleotide exchange factor 15

Rho guanine nucleotide exchange factor (GEF) 15

ARHGEF15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARHGEF15 O94989 PRKG1 Homo sapiens Q13976-2
Validated Y2H
32296183
Intra ARHGEF15 O94989 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra ARHGEF15 O94989 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Array
26871637
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Validated Y2H
26871637
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
26871637
Intra ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Ohtahara Syndrome
Spastic Ataxia, Charlevoix-Saguenay Type

Charlevoix-Saguenay Spastic Ataxia

Autosomal Recessive Spastic Ataxia Of Charlevoix-Saguenay

Arsacs

SACS

Spax6

Spastic Ataxia Charlevoix-Saguenay Type

Spastic Ataxia 6, Autosomal Recessive

Autosomal Recessive Spastic Ataxia Type 6

Spastic Ataxia Of Charlevoix-Saguenay

Atx/Hsp-Sacs

Ataxia, Spastic, Charlevoix-Saguenay Type
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Hypophosphatasia, Childhood

Childhood Hypophosphatasia

Childhood-Onset Hypophosphatasia

HPPC

Childhood-Onset Phosphoethanolaminuria

Childhood-Onset Rathburn Disease

Childhood-Onset Rathbun Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00950 ARHGEF15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARHGEF15 VGNC VGNC:38076
Macaca mulatta ARHGEF15 VGNC VGNC:69832
Rattus norvegicus ARHGEF15 RGD RGD:1306961
Bos taurus ARHGEF15 VGNC VGNC:26107
Mus musculus ARHGEF15 MGD MGI:3045246
Felis catus ARHGEF15 VGNC VGNC:59900
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