NELFE - negative elongation factor complex member E Gene

中文名称：负伸长因子复数成员 E

种属: Homo sapiens

同用名: RD; RDP; RDBP; D6S45; NELF-E

关于 NELFE

功能概要

由该基因编码的蛋白质是称为负延伸因子 (NELF) 的复合物的一部分，它抑制 RNA 聚合酶 II 转录物延伸。该蛋白与核 RNA 结合蛋白具有相似性；但是，尚未证明这种蛋白质与 RNA 结合。该蛋白质含有大量交替的碱性和酸性残基，主要是精氨酸 (R) 和天冬氨酸 (D) 。该基因位于 6 号染色体上的主要组织相容性复合体 (MHC) III 类区域。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]