KAT14 - lysine acetyltransferase 14 Gene

中文名称：赖氨酸乙酰转移酶 14

种属: Homo sapiens

同用名: ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1

基因 ID: 57325 | 基因类型: protein coding

关于 KAT14

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:18,137,153-18,188,372 (from NCBI)

This gene has 13 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in brain (RPKM 8.7), testis (RPKM 8.1) and 25 other tissues.

功能概要

CSRP2 是一种包含两个 LIM 结构域的蛋白质，它们是在具有多种功能的蛋白质中发现的双锌指基序。 CSRP2 和一些相关蛋白质被认为充当蛋白质衔接子，桥接两种或多种蛋白质以形成更大的蛋白质复合物。该基因编码的蛋白质与 CSRP2 的 LIM 结构域之一结合，并包含一个乙酰转移酶结构域。尽管已在细胞质中检测到编码的蛋白质，但它主要是核蛋白。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2011 年 6 月]

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

KAT14 基因产物(15)

mRNA	Protein	Name
NM_001384192.3	NP_001371121.2	cysteine-rich protein 2-binding protein isoform 1
NM_001392069.1	NP_001378998.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392070.1	NP_001378999.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392071.1	NP_001379000.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392072.1	NP_001379001.1	cysteine-rich protein 2-binding protein isoform 1
NM_001392073.1	NP_001379002.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392074.1	NP_001379003.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392075.1	NP_001379004.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392076.1	NP_001379005.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392077.1	NP_001379006.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392078.1	NP_001379007.1	cysteine-rich protein 2-binding protein isoform 2
NM_001392079.1	NP_001379008.1	cysteine-rich protein 2-binding protein isoform 3
NM_001392080.1	NP_001379009.1	cysteine-rich protein 2-binding protein isoform 4
NM_001392081.1	NP_001379010.1	cysteine-rich protein 2-binding protein isoform 5
NM_020536.7	NP_065397.4	cysteine-rich protein 2-binding protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone acetyltransferase activity	IDA IDA: 通过直接分析推断	19103755	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19936620	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	19103755	GOA
involved in regulation of cell division	IDA IDA: 通过直接分析推断	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: 通过突变表型推断	20562830	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ATAC complex	IDA IDA: 通过直接分析推断	18838386	GOA
located in nucleus	IPI IPI: 通过物理相互作用推断	10924333	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT14 蛋白结构

Acetyltransf_1

0
200
400
600
782 a.a.

蛋白主名

其他名称

cysteine-rich protein 2-binding protein

ADA2A-containing complex subunit 2

KAT14 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	25416956
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	KAT14	Q9H8E8	ZFY	Homo sapiens	P08048	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	ZFY	Homo sapiens	P08048	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KAT14	Q9H8E8	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	KAT14	Q9H8E8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	KAT14	Q9H8E8	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Array	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	19060904
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Y2H Array	19060904
Intra	KAT14	Q9H8E8	MBIP	Homo sapiens	Q9NS73	Validated Y2H	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	KAT14	Q9H8E8	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mitochondrial Complex Iv Deficiency, Nuclear Type 19

MC4DN19

Mitochondrial Complex 4 Deficiency, Nuclear Type 19

Buruli Ulcer

Buruli Ulcer, Susceptibility To	Buruli Ulcer Disease
Mycobacterium Ulcerans	Mycobacterium Ulcerans, Susceptibility To
Bairnsdale Ulcer	Daintree Ulcer
Mossman Ulcer	Searl Ulcer
Searle'S Ulcer	Bud

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07073	KAT14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KAT14	RGD	RGD:1309538
Bos taurus	KAT14	VGNC	VGNC:30397
Felis catus	KAT14	VGNC	VGNC:63022
Mus musculus	KAT14	MGD	MGI:1917264
Canis familiaris	KAT14	VGNC	VGNC:42208

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