ZFY - zinc finger protein Y-linked Gene

中文名称：Y 连锁锌指蛋白

种属: Homo sapiens

同用名: ZNF911

基因 ID: 7544 | 基因类型: protein coding

关于 ZFY

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:2,935,381-2,982,506 (from NCBI)

This gene has 7 transcripts (splice variants), 74 orthologues and 38 paralogues. Broad expression in testis (RPKM 3.4), prostate (RPKM 3.2) and 20 other tissues.

功能概要

该基因编码一种含锌指蛋白，可作为转录因子发挥作用。该基因曾是睾丸决定因子 (TDF) 的候选基因，被错误地称为 TDF。[RefSeq 提供，2008 年 7 月]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

ZFY 基因产物(12)

mRNA	Protein	Name
NM_001145275.2	NP_001138747.1	zinc finger Y-chromosomal protein isoform 2
NM_001145276.2	NP_001138748.1	zinc finger Y-chromosomal protein isoform 3
NM_001369702.1	NP_001356631.1	zinc finger Y-chromosomal protein isoform 1
NM_001369703.1	NP_001356632.1	zinc finger Y-chromosomal protein isoform 4
NM_001369704.1	NP_001356633.1	zinc finger Y-chromosomal protein isoform 4
NM_001369705.1	NP_001356634.1	zinc finger Y-chromosomal protein isoform 4
NM_001369706.1	NP_001356635.1	zinc finger Y-chromosomal protein isoform 5
NM_001369707.1	NP_001356636.1	zinc finger Y-chromosomal protein isoform 5
NM_001369708.1	NP_001356637.1	zinc finger Y-chromosomal protein isoform 2
NM_001369709.1	NP_001356638.1	zinc finger Y-chromosomal protein isoform 6
NM_001369710.1	NP_001356639.1	zinc finger Y-chromosomal protein isoform 7
NM_003411.4	NP_003402.2	zinc finger Y-chromosomal protein isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	26871637	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFY 蛋白结构

Zfx_Zfy_act

zf-C2H2

zf-H2C2_5

zf-C2H2

zf-H2C2_5

zf-H2C2_2

zf-C2H2_4

zf-C2H2

zf-H2C2_5

zf-H2C2_2

zf-C2H2

0
200
400
600
801 a.a.

蛋白主名

其他名称

zinc finger Y-chromosomal protein

ZFY 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZFY	P08048	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
种属内	ZFY	P08048	KAT14	Homo sapiens	Q9H8E8	Validated Y2H	32296183
种属内	ZFY	P08048	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Campomelic Dysplasia

Acampomelic Campomelic Dysplasia	Camptomelic Dysplasia
Campomelic Dysplasia With Autosomal Sex Reversal	Cmpd
CMD1	Cmpd1
Cmpd1/Sra1	Acampomelic Campomelic Dysplasia With Autosomal Sex Reversal
Campomelic Dwarfism	Campomelic Syndrome
Dysplasia, Campomelic	Chronic Myeloproliferative Disorder
Familial Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16054	ZFY Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ZFY	MGD	MGI:99153

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