BABAM1 - BRISC and BRCA1 A complex member 1 Gene

中文名称：BRISC 和 BRCA1 复杂成员 1

种属: Homo sapiens

同用名: NBA1; HSPC142; MERIT40; C19orf62

基因 ID: 29086 | 基因类型: protein coding

关于 BABAM1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,267,443-17,279,337 (from NCBI)

This gene has 18 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in brain (RPKM 26.7), placenta (RPKM 25.8) and 25 other tissues.

功能概要

参与多个过程，包括有丝分裂 G2 DNA 损伤检查点信号； DNA 修复的正调控；和蛋白质 K63 连接的去泛素化。位于细胞质和核体中。 BRCA1-A 复合体和 BRISC 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and protein K63-linked deubiquitination. Located in cytosol and nuclear body. Part of BRCA1-A complex and BRISC complex. [provided by Alliance of Genome Resources, Apr 2022]

BABAM1 基因产物(4)

mRNA	Protein	Name
NM_001033549.3	NP_001028721.1	BRISC and BRCA1-A complex member 1 isoform 1
NM_001288756.2	NP_001275685.1	BRISC and BRCA1-A complex member 1 isoform 1
NM_001288757.2	NP_001275686.1	BRISC and BRCA1-A complex member 1 isoform 2
NM_014173.4	NP_054892.2	BRISC and BRCA1-A complex member 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	37398436	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA repair-dependent chromatin remodeling	IMP IMP: 通过突变表型推断	19261746	GOA
involved in double-strand break repair	IMP IMP: 通过突变表型推断	19261746	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	19261746	GOA
involved in positive regulation of DNA repair	IMP IMP: 通过突变表型推断	19261746	GOA
involved in response to ionizing radiation	IMP IMP: 通过突变表型推断	19261748	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of BRCA1-A complex	IDA IDA: 通过直接分析推断	19261746	GOA
part of BRISC complex	IDA IDA: 通过直接分析推断	19214193	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19261749	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19261746	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

BRISC and BRCA1-A complex member 1

BRCA1-A complex subunit MERIT40

BABAM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	BABAM1	Q9NWV8	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	33961781
Intra	BABAM1	Q9NWV8	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	28514442
Intra	BABAM1	Q9NWV8	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	22153077
Intra	BABAM1	Q9NWV8	TNKS2	Homo sapiens	Q9H2K2	FPS	22153077
Intra	BABAM1	Q9NWV8	PMF1	Homo sapiens	Q6P1K2	BiLC	37398436
Intra	BABAM1	Q9NWV8	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	BABAM1	Q9NWV8	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	BABAM1	Q9NWV8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	BABAM1	Q9NWV8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	BABAM1	Q9NWV8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	Y2H Array	31515488
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	Anti Tag CoIP	19615732
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	BRET	37398436
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	BiLC	37398436
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	Anti Tag CoIP	33961781
Intra	BABAM1	Q9NWV8	BABAM2	Homo sapiens	Q9NXR7	Anti Tag CoIP	28514442
Intra	BABAM1	Q9NWV8	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Arthrogryposis, Renal Dysfunction, And Cholestasis 2

ARCS2	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 2
Arthrogryposis Renal Dysfunction And Cholestasis 2

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01331	BABAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	BABAM1	VGNC	VGNC:102005
Macaca mulatta	BABAM1	VGNC	VGNC:70126
Mus musculus	BABAM1	MGD	MGI:1915501
Canis familiaris	BABAM1	VGNC	VGNC:57303
Rattus norvegicus	BABAM1	RGD	RGD:1359516
Bos taurus	BABAM1	VGNC	VGNC:55198

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BABAM1 - BRISC and BRCA1 A complex member 1 Gene

关于 BABAM1

功能概要

BABAM1 基因产物(4)

BABAM1 蛋白互作信息

关联疾病

直系同源

热门区域

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BABAM1 - BRISC and BRCA1 A complex member 1 Gene

关于 BABAM1

功能概要

BABAM1 基因产物(4)

BABAM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z