RBM23 - RNA binding motif protein 23 Gene

中文名称：RNA 结合基序蛋白 23

种属: Homo sapiens

同用名: PP239; RNPC4; CAPERbeta

基因 ID: 55147 | 基因类型: protein coding

关于 RBM23

This gene has 33 transcripts (splice variants), 99 orthologues and 36 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), ovary (RPKM 12.8) and 25 other tissues.

功能概要

该基因编码 RNA 结合蛋白 U2AF 样家族的成员。这种蛋白质与一些类固醇核受体相互作用，定位于类固醇反应基因的启动子，并以激素依赖性方式增加类固醇反应转录报告基因的转录。它还涉及可变剪接的类固醇受体依赖性调节。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBM23 基因产物(9)

mRNA	Protein	Name
NM_001077351.2	NP_001070819.1	probable RNA-binding protein 23 isoform 1
NM_001077352.2	NP_001070820.1	probable RNA-binding protein 23 isoform 3
NM_001308044.2	NP_001294973.1	probable RNA-binding protein 23 isoform 4
NM_001352762.2	NP_001339691.1	probable RNA-binding protein 23 isoform 4
NM_001352763.2	NP_001339692.1	probable RNA-binding protein 23 isoform 1
NM_001352764.2	NP_001339693.1	probable RNA-binding protein 23 isoform 5
NM_001352765.2	NP_001339694.1	probable RNA-binding protein 23 isoform 2
NM_001352766.2	NP_001339695.1	probable RNA-binding protein 23 isoform 1
NM_018107.5	NP_060577.3	probable RNA-binding protein 23 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22365833	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15694343	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	15694343	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBM23 蛋白结构

RRM_1

RBM39linker

0
100
200
300
400
439 a.a.

蛋白主名

其他名称

probable RNA-binding protein 23

CAPER beta

RBM23 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RBM23	Q86U06	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	RBM23	Q86U06	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	RBM23	Q86U06	PRMT5	Homo sapiens	O14744	Y2H	23455924
Intra	RBM23	Q86U06	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	RBM23	Q86U06	SRPK2	Homo sapiens	P78362	Y2H	22365833
Intra	RBM23	Q86U06	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	RBM23	Q86U06	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	TRIM27	Homo sapiens	P14373	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Posterior Uveal Melanoma

Medium/Large Size Posterior Uveal Melanoma	Small Size Posterior Uveal Melanoma
Ciliary Body And Choroid Melanoma, Medium/Large Size	Ciliary Body And Choroid Melanoma, Small Size

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