FBXW5 - F-box and WD repeat domain containing 5 Gene

中文名称：含 F-box 和 WD 重复结构域 5

种属: Homo sapiens

同用名: Fbw5

关于 FBXW5

功能概要

该基因编码 F-box 蛋白家族的一个成员，其成员的特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为三类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质含有 WD-40 结构域，另外还有一个 F-box 基序，因此属于 Fbw 类。已经为该基因鉴定了编码不同亚型的选择性剪接转录物变体，但是，它们被发现是无义介导的 mRNA 衰变 (NMD) 候选者，因此没有代表。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]