2. Gene
  3. ILF2 - interleukin enhancer binding factor 2 Gene

ILF2 - interleukin enhancer binding factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素增强子结合因子 2

种属: Homo sapiens

同用名: NF45; PRO3063

基因 ID: 3608 | 基因类型: protein coding

关于 ILF2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,661,788-153,670,993 (from NCBI)

This gene has 5 transcripts (splice variants), 248 orthologues and 14 paralogues. Ubiquitous expression in testis (RPKM 65.5), bone marrow (RPKM 58.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是 T 细胞表达白细胞介素 2 基因所需的转录因子。它还结合 RNA，是乙型肝炎病毒聚合酶衣壳化和蛋白启动的重要组成部分。编码的 45 kDa 蛋白 (NF45、ILF2) 与 90 kDa 白介素增强子结合因子 3 (NF90、ILF3) 形成复合物，该复合物已被证明会影响核 mRNA 向细胞质的重新分布，从而修复 DNA 断裂通过非同源末端连接，并负向调节 MicroRNA 加工途径。 NF45 或 NF90 蛋白的敲低可能通过抑制 mRNA 稳定来延迟细胞生长。可变剪接导致多个转录本变体。在 3 号和 14 号染色体上发现了相关的假基因。[RefSeq 提供，2014 年 12 月]

The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the MicroRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

ILF2 基因产物(2)

mRNA Protein Name
NM_001267809.2 NP_001254738.1 interleukin enhancer-binding factor 2 isoform 2
NM_004515.4 NP_004506.2 interleukin enhancer-binding factor 2 isoform 1

ILF2 蛋白结构

DZF

DZF: DZF domain (104 - 337)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

interleukin enhancer-binding factor 2

interleukin enhancer binding factor 2, 45kD

重组 ILF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700525 ILF2 Protein, Human (GST) Q12905 (M1-E390) ≥95%

关联疾病

疾病名称 别名
Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Childhood Endodermal Sinus Tumor

Childhood Endodermal Sinus Neoplasm

Childhood Endodermal Sinus Tumour

Paediatric Yolk Sac Tumour

Pediatric Yolk Sac Tumor

Childhood Yolk Sac Tumor
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06785 ILF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ILF2 MGD MGI:1915031
Felis catus ILF2 VGNC VGNC:67790
Rattus norvegicus ILF2 RGD RGD:1305734
Macaca mulatta ILF2 VGNC VGNC:99982
Canis familiaris ILF2 VGNC VGNC:41999
Bos taurus ILF2 VGNC VGNC:30175
Others ILF2 NCBI
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