NEIL2 - nei like DNA glycosylase 2 Gene

中文名称：nei 样 DNA 糖基化酶 2

种属: Homo sapiens

同用名: NEH2; NEI2

关于 NEIL2

功能概要

该基因编码 DNA 糖基化酶 Fpg/Nei 家族的成员。这些糖基化酶通过切割氧化损伤的碱基并通过其脱碱基位点裂解酶活性引入 DNA 链断裂，从而启动碱基切除修复的第一步。这种酶主要与转录过程中的 DNA 修复有关，并且优先作用于胞嘧啶衍生的损伤，尤其是 5-羟基尿嘧啶和 5-羟基胞嘧啶。它包含一个 N 端催化结构域、一个铰链区和一个具有螺旋-双转角-螺旋和锌指基序的 C 端 DNA 结合结构域。这种酶与 X 射线交叉互补因子 1 支架蛋白相互作用，作为多蛋白 DNA 修复复合物的一部分。已鉴定出该基因的假基因。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This Enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This Enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]