VAV3 - vav guanine nucleotide exchange factor 3 Gene

中文名称：vav 鸟嘌呤核苷酸交换因子 3

种属: Homo sapiens

基因 ID: 10451 | 基因类型: protein coding

关于 VAV3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,571,161-107,965,180 (from NCBI)

This gene has 15 transcripts (splice variants), 296 orthologues and 22 paralogues. Broad expression in kidney (RPKM 10.0), skin (RPKM 8.3) and 17 other tissues.

功能概要

该基因是 VAV 基因家族的成员。 VAV 蛋白是 Rho 家族 GTP 酶的鸟嘌呤核苷酸交换因子 (GEF) ，可激活导致肌动蛋白细胞骨架重排和转录改变的通路。该基因产物作为 GEF 优先用于 RhoG、RhoA，并在较小程度上作为 RAC1，并且它与这些 GTP 酶的无核苷酸状态最大限度地相关联。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

VAV3 基因产物(2)

mRNA	Protein	Name
NM_001079874.2	NP_001073343.1	guanine nucleotide exchange factor VAV3 isoform 2
NM_006113.5	NP_006104.4	guanine nucleotide exchange factor VAV3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables guanyl-nucleotide exchange factor activity	EXP EXP: 通过实验结果推断	8990121	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12577067	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell receptor signaling pathway	IMP IMP: 通过突变表型推断	17875758	GOA
involved in DNA damage response	IMP IMP: 通过突变表型推断	17875758	GOA
involved in positive regulation of B cell proliferation	IMP IMP: 通过突变表型推断	17875758	GOA
involved in regulation of GTPase activity	IGI IGI: 通过遗传相互作用推断	22467863	GOA
NOT involved in regulation of cell size	IGI IGI: 通过遗传相互作用推断	22467863	GOA
involved in regulation of cell size	IGI IGI: 通过遗传相互作用推断	22467863	GOA
involved in response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	17875758	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in immunological synapse	IDA IDA: 通过直接分析推断	15708849	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAV3 蛋白结构

CAMSAP_CH

RhoGEF

C1_1

SH3_2

SH2

SH3_2

0
200
400
600
800
847 a.a.

蛋白主名

其他名称

guanine nucleotide exchange factor VAV3

VAV-3

VAV3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VAV3	Q9UKW4	MET	Homo sapiens	P08581	FPS	24728074
Intra	VAV3	Q9UKW4	GRB2	Homo sapiens	P62993	Y2H	18654987
Intra	VAV3	Q9UKW4	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	VAV3	Q9UKW4	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	VAV3	Q9UKW4	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	VAV3	Q9UKW4	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	VAV3	Q9UKW4	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	VAV3	Q9UKW4	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	VAV3	Q9UKW4	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	VAV3	Q9UKW4	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	VAV3	Q9UKW4	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	32296183
Intra	VAV3	Q9UKW4	CBLB	Homo sapiens	Q13191	Y2H Array	32296183
Intra	VAV3	Q9UKW4	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	16982329

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Anterior Foramen Magnum Meningioma

Meningioma Of The Anterior Foramen Magnum

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15614	VAV3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	VAV3	MGD	MGI:1888518
Bos taurus	VAV3	VGNC	VGNC:36774
Rattus norvegicus	VAV3	RGD	RGD:1565941
Canis familiaris	VAV3	VGNC	VGNC:48237
Macaca mulatta	VAV3	VGNC	VGNC:78759
Felis catus	VAV3	VGNC	VGNC:66927

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