1. Gene
  2. CCNK - cyclin K Gene

CCNK - cyclin K Gene

中文名称:细胞周期蛋白 K

种属: Homo sapiens

同用名: CPR4; IDDHDF

基因 ID: 8812 | 基因类型: protein coding

关于 CCNK

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,481,409-99,512,440 (from NCBI)

This gene has 9 transcripts (splice variants), 169 orthologues, 6 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 33.7), testis (RPKM 31.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是转录细胞周期蛋白家族的成员。这些细胞周期蛋白可能通过它们与细胞周期蛋白依赖性激酶 (CDK) 的结合和激活来调节转录,CDK 磷酸化 RNA 聚合酶 II 大亚基的 C 末端结构域 (CTD) 。该基因产物可能在调节 CDK 和 RNA 聚合酶 II 活性方面发挥双重作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

CCNK 基因产物(1)

mRNA Protein Name
NM_001099402.2 NP_001092872.1 cyclin-K
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: 通过直接分析推断
9632813 GOA
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9632813 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
22012619 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
22012619 GOA
involved in negative regulation by host of viral genome replication IDA
IDA: 通过直接分析推断
21555514 GOA
involved in positive regulation of transcription elongation by RNA polymerase II IDA
IDA: 通过直接分析推断
22988298 GOA
involved in regulation of signal transduction IDA
IDA: 通过直接分析推断
26748711 GOA
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22988298 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin K-CDK12 complex IPI
IPI: 通过物理相互作用推断
22012619 GOA
part of cyclin K-CDK13 complex IPI
IPI: 通过物理相互作用推断
22012619 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCNK 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (35 - 155)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
蛋白主名 其他名称

cyclin-K

CCNK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNK O75909 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
种属内
CCNK O75909 NDC80 Homo sapiens O14777
Validated Y2H
25416956
种属内
CCNK O75909 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
种属内
CCNK O75909 RBPMS Homo sapiens Q93062
Y2H Array
25416956
种属内
CCNK O75909 RBPMS Homo sapiens Q93062
Y2H Pooling
16189514
种属内
CCNK O75909 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
种属内
CCNK O75909 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
种属内
CCNK O75909 ATXN1 Homo sapiens P54253
Y2H Array
16713569
种属内
CCNK O75909 CDK13 Homo sapiens Q14004
GMS
26748711
种属内
CCNK O75909 CDK13 Homo sapiens Q14004
X-Ray Diffraction
26748711
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder With Hypertelorism And Distinctive Facies

IDDHDF

Ccnk-Related Neurodevelopmental Disorder-Severe Intellectual Disability-Facial Dysmorphism Syndrome
Kaposi Sarcoma

Kaposi'S Sarcoma

Kaposi Sarcoma, Susceptibility To

Kaposi'S Sarcoma Of Lung

Kaposi'S Sarcoma Of Palate

Kaposi'S Sarcoma Of Soft Tissue

Kaposi'S Sarcoma-Associated Herpesvirus

Multiple Idiopathic Pigmented Hemangiosarcoma

Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

African Lymphadenopathic Kaposi'S Sarcoma

Anal Kaposi'S Sarcoma

Cardiac Kaposi'S Sarcoma

Central Nervous System Kaposi'S Sarcoma

Conjunctival Kaposi'S Sarcoma

Corneal Kaposi'S Sarcoma

Cutaneous Kaposi'S Sarcoma

Esophageal Kaposi'S Sarcoma

Gallbladder Kaposi'S Sarcoma

Gastric Kaposi'S Sarcoma

Intestinal Kaposi'S Sarcoma

Kaposi'S Sarcoma Of Anus

Kaposi'S Sarcoma Of Central Nervous System

Kaposi'S Sarcoma Of Conjunctiva

Kaposi'S Sarcoma Of Cornea

Kaposi'S Sarcoma Of Esophagus

Kaposi'S Sarcoma Of Gastrointestinal Sites

Kaposi'S Sarcoma Of Heart

Kaposi'S Sarcoma Of Lymph Nodes

Kaposi'S Sarcoma Of Penis

Kaposi'S Sarcoma Of Skin

Kaposi'S Sarcoma Of Soft Tissues

Kaposi'S Sarcoma Of The Cns

Kaposi'S Sarcoma Of The Gallbladder

Kaposi'S Sarcoma Of The Prostate

Kaposi'S Sarcoma, Lung

Kaposi'S Sarcoma, Skin

Lymph Node Kaposi'S Sarcoma

Lymphadenopathic Kaposi'S Sarcoma

Palate Kaposi'S Sarcoma

Penis Kaposi'S Sarcoma

Prostate Kaposi'S Sarcoma

Pulmonary Kaposi'S Sarcoma

Soft Tissue Kaposi'S Sarcoma

Hhv8

Human Herpesvirus 8

Kshv

Kaposi Sarcoma Herpesvirus

Mediterranean Kaposi Sarcoma

Non Aids Related Kaposi Sarcoma

Sarcoma, Kaposi

Sarcoma, Kaposi, Susceptibility To

Non-Aids-Related Kaposi Sarcoma

Angiolymphoid Hyperplasia

Angiofollicular Ganglionic Hyperplasia

Multi-Centric Castleman'S Disease

Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD

Cdk13-Related Disorder

Cdk13-Related Chdfidd

Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder

Developmental And Epileptic Encephalopathy 66

DEE66

Epileptic Encephalopathy, Early Infantile, 66

Eiee66

Developmental And Epileptic Encephalopathy, 66

Early Infantile Epileptic Encephalopathy 66

Encephalopathy, Epileptic, Early Infantile, Type 66

Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea

Chandler Syndrome

CHED

Chandler'S Syndrome

Endothelial Corneal Dystrophy

Ched2

Maumenee Corneal Dystrophy

Corneal Dystrophy, Congenital Hereditary Endothelial

Dystrophy Of Corneal Endothelium

Corneal Endothelial Dystrophy 2

Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly

Ched2, Formerly

Corneal Endothelial Dystrophy, Autosomal Recessive

Endothelial Dystrophy

Posterior Membrane Corneal Dystrophy

Corneal Endothelial Dystrophy Type 2

Congenital Hereditary Endothelial Dystrophy Of The Cornea

Congenital Hereditary Endothelial Dystrophy Type Ii

Autosomal Recessive Ched

Autosomal Recessive Congenital Hereditary Endothelial Dystrophy

Chedii

Congenital Hereditary Endothelial Dystrophy Type 2

Infantile Hereditary Endothelial Dystrophy

Congenital Hereditary Endothelial Corneal Dystrophy

Corneal Endothelial Dystrophy 2, Autosomal Recessive

Iridocorneal Endothelial Syndrome

Dystrophy, Corneal, Endothelial

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Intellectual Developmental Disorder, Autosomal Dominant 13

MRD13

Mental Retardation, Autosomal Dominant 13

Mental Retardation, Autosomal Dominant 13, With Neuronal Migration Defects

Autosomal Dominant Non-Syndromic Intellectual Disability 13

Autosomal Dominant Intellectual Developmental Disorder 13

Autosomal Dominant Mental Retardation 13

Mental Retardation, Autosomal Dominant, Type 13

Hypertelorism

Eyes Wide Apart

Eyes Widely Set

Hypertelorism Of Orbit

Ocular Hypertelorism

Orbital Separation Excessive

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CCNK MGD MGI:1276106
Rattus norvegicus CCNK RGD RGD:1595690
Macaca mulatta CCNK VGNC VGNC:70734
Bos taurus CCNK VGNC VGNC:26974
Felis catus CCNK VGNC VGNC:60565
Canis familiaris CCNK VGNC VGNC:38904
Others CCNK NCBI