CDK13 - cyclin dependent kinase 13 Gene

中文名称：细胞周期蛋白依赖性激酶 13

种属: Homo sapiens

同用名: CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD

基因 ID: 8621 | 基因类型: protein coding

关于 CDK13

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:39,950,256-40,099,580 (from NCBI)

This gene has 23 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是细胞周期蛋白依赖性丝氨酸/苏氨酸蛋白激酶家族的成员。该家族的成员以其在细胞周期控制中作为主开关的重要作用而闻名。这种蛋白质的确切功能尚未确定，但它可能在 mRNA 加工中发挥作用，并可能参与造血调节。已经描述了选择性剪接的转录变体。[RefSeq 提供，2009 年 12 月]

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

CDK13 基因产物(5)

mRNA	Protein	Name
NM_003718.5	NP_003709.3	cyclin-dependent kinase 13 isoform 1
XM_017012751.3	XP_016868240.1	cyclin-dependent kinase 13 isoform X2
XM_011515597.4	XP_011513899.1	cyclin-dependent kinase 13 isoform X3
NM_031267.3	NP_112557.2	cyclin-dependent kinase 13 isoform 2
XM_017012750.3	XP_016868239.1	cyclin-dependent kinase 13 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: 通过直接分析推断	20952539	GOA
enables cyclin binding	IPI IPI: 通过物理相互作用推断	22012619	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16721827	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in hemopoiesis	IMP IMP: 通过突变表型推断	1731328	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20952539	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	26748711	GOA
involved in regulation of signal transduction	IDA IDA: 通过直接分析推断	26748711	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cyclin K-CDK13 complex	IPI IPI: 通过物理相互作用推断	22012619	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	16721827	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK13 蛋白结构

Pkinase

0
300
600
900
1200
1512 a.a.

蛋白主名

其他名称

cyclin-dependent kinase 13

CDC2-related protein kinase 5	cell division cycle 2-like protein kinase 5
cell division protein kinase 13	cholinesterase-related cell division controller

CDK13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDK13	Q14004	CDC37	Homo sapiens	Q16543	Pull Down	32707033
种属内	CDK13	Q14004	CCNK	Homo sapiens	O75909	Pull Down	32707033
种属内	CDK13	Q14004	CCNK	Homo sapiens	O75909	Anti Tag CoIP	35271311
种属内	CDK13	Q14004	CCNK	Homo sapiens	O75909	Protein Kinase Assay	26748711
种属内	CDK13	Q14004	CCNK	Homo sapiens	O75909	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinitis Pigmentosa 62

RP62	Retinitis Pigmentosa, Type 62

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD	Cdk13-Related Chdfidd
Cdk13-Related Disorder	Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

White-Sutton Syndrome

WHSUS	Mrd37
Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome	Mental Retardation, Autosomal Dominant 37
Autosomal Dominant Mental Retardation 37	Pogz-Related Intellectual Disability Syndrome

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea	Chandler Syndrome
CHED	Chandler'S Syndrome
Endothelial Corneal Dystrophy	Ched2
Maumenee Corneal Dystrophy	Corneal Dystrophy, Congenital Hereditary Endothelial
Dystrophy Of Corneal Endothelium	Corneal Endothelial Dystrophy 2
Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly	Ched2, Formerly
Corneal Endothelial Dystrophy, Autosomal Recessive	Endothelial Dystrophy
Posterior Membrane Corneal Dystrophy	Corneal Endothelial Dystrophy Type 2
Congenital Hereditary Endothelial Dystrophy Of The Cornea	Congenital Hereditary Endothelial Dystrophy Type Ii
Autosomal Recessive Ched	Autosomal Recessive Congenital Hereditary Endothelial Dystrophy
Chedii	Congenital Hereditary Endothelial Dystrophy Type 2
Infantile Hereditary Endothelial Dystrophy	Congenital Hereditary Endothelial Corneal Dystrophy
Corneal Endothelial Dystrophy 2, Autosomal Recessive	Iridocorneal Endothelial Syndrome
Dystrophy, Corneal, Endothelial	Corneal Endothelial Dystrophy 1, Autosomal Dominant

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-80013	THZ1	Inhibitor	99.84%	否
HY-103618	THZ531	Inhibitor	99.86%	否
HY-130250	SR-4835	Inhibitor	99.73%	否
HY-80013A	THZ1 Hydrochloride	Inhibitor	98.61%	否
HY-151110A	PROTAC CDK12/13 Degrader-1 TFA	Degrader	98.37%	否
HY-145072	BSJ-01-175	Inhibitor	99.45%	否
HY-151110	PROTAC CDK12/13 Degrader-1	Degrader	98.01%	否
HY-168555	YJ1206	Degrader	/	否
HY-168556	YJ9069	Degrader	/	否
HY-168162	ZLC491	Degrader	/	否
HY-150641	CDK-IN-9	Inhibitor	/	否
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	否
HY-158170	CDK7-IN-28	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CDK13	RGD	RGD:1311226
Canis familiaris	CDK13	VGNC	VGNC:39045
Mus musculus	CDK13	MGD	MGI:1916812
Bos taurus	CDK13	VGNC	VGNC:27118
Macaca mulatta	CDK13	VGNC	VGNC:70966
Felis catus	CDK13	VGNC	VGNC:60695
Others	CDK13	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4