2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK7-IN-28

CDK7-IN-28 (CDK7-1276) 是一种有效的 CDK7 抑制剂 (IC50<5 nM)。 CDK7-IN-28 通过阻滞细胞周期和抑制 DNA 复制来实现对 MDA-MB-468 细胞系抗增殖作用。

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CDK7-IN-28 Chemical Structure

CDK7-IN-28 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

CDK7-IN-28 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication[1].

IC50 & Target[1]

CDK7/Cyclin H/MNAT1

＜5 nM (IC50)

cdk2/cyclin A

6224 nM (IC50)

CDK9/CyclinA

296 nM (IC50)

CDK13/Cyclin K

152 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-28 对 MDA-MB-468 细胞(IC50=2 nM)， HepaRG 细胞(IC50＜10 nM)， NAl-H82 (IC50＜10 nM) 有较好的抗增殖活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK7-IN-28 相关抗体:

Cell Proliferation Assay

Cell Line:
Concentration:
Incubation Time:
Result:
分子量

460.50

Formula

C23H27F3N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK7-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK7-IN-28CDKCyclin dependent kinaseCDK InhibitorMDA-MB-468 cellsInhibitorinhibitorinhibit

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产品名称：
CDK7-IN-28
目录号：
HY-158170
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