2. Gene
  3. KRT6B - keratin 6B Gene

KRT6B - keratin 6B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：角蛋白 6B

种属: Homo sapiens

同用名: K6B; PC2; PC4; CK6B; CK-6B; KRTL1

基因 ID: 3854 | 基因类型: protein coding

关于 KRT6B

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,446,651-52,452,146 (from NCBI)

This gene has 1 transcript (splice variant), 143 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 785.7).

功能概要

该基因编码的蛋白质是角蛋白基因家族的一员。 II 型细胞角蛋白由碱性或中性蛋白组成，这些蛋白排列成对异型角蛋白链，在单层和复层上皮组织分化过程中共同表达。已鉴定出多达六种这种 II 型细胞角蛋白 (KRT6) ；基因的多样性归因于连续的基因复制事件。这些基因与家族成员 KRT16 和/或 KRT17 在舌头的丝状乳头、口腔粘膜和食道的分层上皮衬里、毛囊的外根鞘和腺体上皮细胞中表达。这些基因的突变与先天性厚甲症有关。 II 型细胞角蛋白聚集在染色体 12q12-q13 的区域中。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT6B 基因产物(1)

mRNA Protein Name
NM_005555.4 NP_005546.2 keratin, type II cytoskeletal 6B
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT6B 蛋白结构

Filament

Filament: Intermediate filament protein (162 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
蛋白主名 其他名称

keratin, type II cytoskeletal 6B

cytokeratin 6B

KRT6B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KRT6B P04259 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
种属内
KRT6B P04259 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
种属内
KRT6B P04259 KRT37 Homo sapiens O76014
Y2H Array
32296183
种属内
KRT6B P04259 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT38 Homo sapiens O76015
Validated Y2H
25416956
种属内
KRT6B P04259 KRT38 Homo sapiens O76015
Y2H Array
32296183
种属内
KRT6B P04259 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT38 Homo sapiens O76015
MAPPIT
32296183
种属内
KRT6B P04259 KRT33B Homo sapiens Q14525
Y2H Array
32296183
种属内
KRT6B P04259 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
种属内
KRT6B P04259 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT35 Homo sapiens Q92764
Y2H Array
32296183
种属内
KRT6B P04259 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
种属内
KRT6B P04259 TUBGCP4 Homo sapiens Q9UGJ1-2
Y2H Array
32296183
种属内
KRT6B P04259 TUBGCP4 Homo sapiens Q9UGJ1-2
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 TUBGCP4 Homo sapiens Q9UGJ1-2
Validated Y2H
32296183
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
种属内
KRT6B P04259 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
种属内
KRT6B P04259 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
种属内
KRT6B P04259 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 TEX11 Homo sapiens Q8IYF3-3
Validated Y2H
32296183
种属内
KRT6B P04259 KRT39 Homo sapiens Q6A163
Validated Y2H
32296183
种属内
KRT6B P04259 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
种属内
KRT6B P04259 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
种属内
KRT6B P04259 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
种属内
KRT6B P04259 KRT28 Homo sapiens Q7Z3Y7
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT28 Homo sapiens Q7Z3Y7
Validated Y2H
32296183
种属内
KRT6B P04259 KRT28 Homo sapiens Q7Z3Y7
Y2H Array
32296183
种属内
KRT6B P04259 KRT13 Homo sapiens P13646
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT13 Homo sapiens P13646
Validated Y2H
32296183
种属内
KRT6B P04259 KRT13 Homo sapiens P13646
Y2H Array
32296183
种属内
KRT6B P04259 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
种属内
KRT6B P04259 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
种属内
KRT6B P04259 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
种属内
KRT6B P04259 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
种属内
KRT6B P04259 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
种属内
KRT6B P04259 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
种属内
KRT6B P04259 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
种属内
KRT6B P04259 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 NUP62 Homo sapiens P37198
Validated Y2H
32296183
种属内
KRT6B P04259 NUP62 Homo sapiens P37198
Y2H Array
32296183
种属内
KRT6B P04259 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 OIP5 Homo sapiens O43482
Y2H Array
32296183
种属内
KRT6B P04259 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
种属内
KRT6B P04259 NDC80 Homo sapiens O14777
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT15 Homo sapiens P19012
Y2H Array
32296183
种属内
KRT6B P04259 KRT15 Homo sapiens P19012
Y2H Pooling
16189514
种属内
KRT6B P04259 KRT15 Homo sapiens P19012
Validated Y2H
32296183
种属内
KRT6B P04259 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
种属内
KRT6B P04259 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT19 Homo sapiens P08727
Validated Y2H
32296183
种属内
KRT6B P04259 KRT19 Homo sapiens P08727
Y2H Array
32296183
种属内
KRT6B P04259 KRT19 Homo sapiens P08727
Y2H Pooling
16189514
种属内
KRT6B P04259 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属内
KRT6B P04259 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属内
KRT6B P04259 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
种属内
KRT6B P04259 KRT31 Homo sapiens Q15323
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

KRT6B 抗体

目录号 产品名 应用 反应物种
HY-P81956 Cytokeratin 6 Antibody (YA1701) WB, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Pachyonychia Congenita 4

PC4

Pachyonychia Congenita, Type 4
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Pachyonychia Congenita 2

Pachyonychia Congenita, Type 2

PC2

Pachyonychia Congenita, Jackson-Lawler Type, Formerly

Pachyonychia Congenita Jackson-Lawler Type
Median Rhomboid Glossitis

Persistent Tuberculum Impar

Glossitis Rhomboidea Mediana

Superficial Midline Glossitis
Glossitis

Inflammation Of Tongue

Tongue Inflammation

Glazed Tongue
Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Cataract 38

CTRCT38

Catc5

Autosomal Recessive Congenital Cataract 5

Cataract, Autosomal Recessive Congenital 5

Cataract 38, Autosomal Recessive

Cataract, Type 38
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma

Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

FNEPPK1

Ppkfne

Keratoderma, Focal Nonepidermolytic Palmoplantar

Palmoplantar Keratoderma, Nonepidermolytic, Focal

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Fneppk

Focal Nonepidermolytic Palmoplantar Keratoderma 1

Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM
Focal Palmoplantar Keratoderma

Focal Ppk

Focal Keratosis Palmoplantaris

Focal Palmoplantar Hyperkeratosis
Occupational Dermatitis

Dermatitis, Occupational

Occupational Allergic Contact Dermatitis

Occupational Eczema
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
Naegeli-Franceschetti-Jadassohn Syndrome

Naegeli Syndrome

Nfj Syndrome

NFJS

Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy

Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis

Dpr

Franceschetti-Jadassohn Syndrome

Nfjs/Dpr
White Sponge Nevus 1

White Sponge Nevus Of Cannon

Leukokeratosis, Hereditary Mucosal

Hereditary Mucosal Leukokeratosis

White Sponge Nevus

WSN1

Wsn

Cannon'S Disease

Familial White Folded Mucosal Dysplasia

Hereditary Leukokeratosis

Hereditary Oral Keratosis

Leukokeratosis Of Oral Mucosa

Nevus Of Cannon

White Folded Gingivostomatosis

White Gingivostomatitis

White Sponge Naevus

White Sponge Nevus Of Mucosa
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome
Palmoplantar Keratosis

Palmoplantar Keratoderma

Keratosis Palmaris Et Plantaris

Palmo-Plantar Keratodermas

Keratoderma, Palmoplantar

Keratoderma Palmoplantar

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis Of Palms And Soles

Palmoplantar Hyperkeratosis
Angular Cheilitis

Cheilosis

Angular Cheilosis

Angular Stomatitis

Commissural Cheilitis
Epidermolysis Bullosa Simplex 1a, Generalized Severe

Epidermolysis Bullosa Simplex, Dowling-Meara Type

Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type

EBS1A

Ebsdm

Epidermolysis Bullosa Simplex Dowling-Meara Type

Epidermolysis Bullosa Simplex, Herpetiformis

Ebs-Dm

Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type

Ebs-Gen Sev

Epidermolysis Bullosa Herpetiformis Dowling-Meara Type

Generalized Severe Epidermolysis Bullosa Simplex

Dowling-Meara Type Epidermolysis Bullosa Simplex

Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form

Autosomal Dominant Generalized Ebs, Severe Form

Epidermolysis Bullosa Simplex Herpetiformis

Dm-Ebs

Epidermolysis Bullosa Simplex, Generalized Severe

Epidermolysis Bullosa Herpetiformis, Dowling-Meara

Epidermolysis Bullosa Herpetiformis Dowling-Meara
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07459 KRT6B Human Pre-designed siRNA Set A Pre-designed Sets / 否
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z