VPS72 - vacuolar protein sorting 72 homolog Gene

中文名称：液泡蛋白分选 72 同系物

种属: Homo sapiens

同用名: YL1; CFL1; Swc2; YL-1; TCFL1

关于 VPS72

功能概要

该基因编码的蛋白质是两个多组分复合物的共享亚基，即组蛋白乙酰转移酶复合物 TRRAP/TIP60 以及含有染色质重塑 SRCAP 的复合物。 TRRAP/TIP60 复合物乙酰化对转录调节、双链 DNA 断裂修复和细胞凋亡很重要的核小体组蛋白。含有 SRCAP 的复合物催化组蛋白 H2A 与组蛋白变体 Htz1 (H2AFZ) 交换到核小体中。这种蛋白质可能负责结合 H2AFZ，后者在染色体分离中起作用。这种蛋白质也可能在调节长期造血干细胞活性方面发挥作用。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a shared subunit of two multi-component complexes, the Histone Acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and Apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]