1. Gene
  2. AIP - aryl hydrocarbon receptor interacting protein Gene

AIP - aryl hydrocarbon receptor interacting protein Gene

中文名称:芳烃受体相互作用蛋白

种属: Homo sapiens

同用名: ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN

基因 ID: 9049 | 基因类型: protein coding

关于 AIP

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,483,026-67,491,103 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues, 1 paralogue and is associated with 8 phenotypes. Ubiquitous expression in lymph node (RPKM 29.1), spleen (RPKM 26.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是芳基烃的受体和配体激活的转录因子。编码的蛋白质作为多蛋白复合物的一部分存在于细胞质中,但在与配体结合后被转运到细胞核。这种蛋白质可以调节许多异生物质代谢酶的表达。此外,编码的蛋白质可以特异性结合并抑制乙型肝炎病毒的活性。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供,2014 年 12 月]

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing Enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

AIP 基因产物(3)

mRNA Protein Name
NM_001302959.2 NP_001289888.1 AH receptor-interacting protein isoform 2
NM_001302960.2 NP_001289889.1 AH receptor-interacting protein isoform 3
NM_003977.4 NP_003968.3 AH receptor-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GAF domain binding IDA
IDA: 通过直接分析推断
17329248 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14557246 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
14557246 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein maturation by protein folding IDA
IDA: 通过直接分析推断
14557246 GOA
involved in protein targeting to mitochondrion IDA
IDA: 通过直接分析推断
14557246 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17329248 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
17329248 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AIP 蛋白结构

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (29 - 90)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

AH receptor-interacting protein

Ah receptor activated 9

AIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AIP O00170 PDE2A Homo sapiens O00408 17329248
种属内
AIP O00170 PDE2A Homo sapiens O00408
Y2H
17329248
种属内
AIP O00170 EGFR Homo sapiens P00533 31980649
种属内
AIP O00170 HSP90AB1 Homo sapiens P08238 28634279
种属内
AIP O00170 HSP90AB1 Homo sapiens P08238 19375531
种属内
AIP O00170 HSP90AB1 Homo sapiens P08238 21170051
种属内
AIP O00170 HSP90AB1 Homo sapiens P08238 25036637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pituitary Adenoma 1, Multiple Types

Pituitary Adenoma Predisposition

PITA1

Isolated Familial Somatotropinoma

Fis

Ifs

Somatotrophinoma, Familial

Acromegaly Due To Pituitary Adenoma 1

Pagh1

Pituitary Adenoma 1

Somatotropinoma, Familial Isolated

Somatotropic Adenoma

Somatotropinoma

Pituitary Gigantism

Hypophyseal Gigantism

Infantile And Juvenile Forms Of Acromegaly

Acromegaly Due To Pituitary Adenoma

Familial Isolated Pituitary Adenoma

Familial Isolated Somatotropinomas

Familial Somatotrophinoma

Fipa

Pituitary Adenoma, Growth Hormone-Secreting, 1

Gigantism Pituitary

Pituitary Adenoma, Type 1, Multiple Types

Gigantism

Pituitary Adenoma, Familial Isolated

Multiple Gastrointestinal Atresias

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma

Growth Hormone Producing Adenoma Of The Pituitary

Growth Hormone Secreting Adenoma Of Pituitary

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome

Common Syndrome

Bap1 Cancer Syndrome

Bap1-Tpds

Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms

Tumor Predisposition Syndrome

Tumor Susceptibility Linked To Germline Bap1 Mutations

Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms

Tumor Predisposition

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome

Fipa

Gastrointestinal Defects And Immunodeficiency Syndrome

Multiple Gastrointestinal Atresias

Familial Isolated Pituitary Adenoma

Intestinal Atresia, Multiple

Multiple Intestinal Atresia

GIDID1

Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Minat

Gidid

Meddra:10028210

Familial Isolated Pituitary Adenoma Syndrome

Intestinal Atresia Multiple

Combined Immunodeficiency-Enteropathy Spectrum

Cid-Mia/Early-Onset Ibd

Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Mia

Gastrointestinal Defect And Immunodeficiency Syndrome

Pituitary Adenoma Predisposition

Pituitary Adenoma, Familial Isolated

Acromegaly

Gigantism

Growth Hormone Excess

Pituitary Giant

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma

Prolactin-Secreting Pituitary Adenoma

Forbes-Albright Syndrome

Lactotroph Adenoma

Prl-Secreting Pituitary Adenoma

Prloma

Pituitary Lactotrophic Adenoma

Familial Prolactinoma

Pituitary Adenoma, Prolactin-Secreting

Prolactinoma Of Pituitary Gland

PSPA

Silent Pituitary Adenoma

Non-Functioning Pituitary Gland Neoplasm

Null Pituitary Adenoma
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor

Pituitary Tumors, Hormone Producing

Somatotropinoma

Growth Hormone-Producing Pituitary Gland Neoplasm

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Pituitary Adenoma

Adenoma Of The Pituitary Gland

Pituitary Adenomas

Adenoma, Pituitary

Pituitary Gland Adenoma

Pituitary Neoplasms

Pituitary Apoplexy

Pituitary Tumor Apoplexy

Pituitary Cancer

Pituitary Carcinoma

Malignant Pituitary Neoplasm

Malignant Tumor Of Pituitary Gland

Neoplasm Of Pituitary Gland

Pituitary Gland Cancer

Pituitary Gland Neoplasm

Pituitary Neoplasm

Carcinoma Of The Pituitary Gland

Neoplasm Of The Pituitary Gland

Pituitary Neoplasms

Malignant Neoplasm Of Pituitary Gland

Lissencephaly, X-Linked, 2

X-Linked Lissencephaly With Abnormal Genitalia

Hydranencephaly With Abnormal Genitalia

Xlag

Xlisg

X-Linked Lissencephaly With Ambiguous Genitalia

LISX2

Lissencephaly, X-Linked 2

X-Linked Lissencephaly 2

X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome

Xlag Syndrome

Lissencephaly, X-Linked, With Ambiguous Genitalia

Xlis2

X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies

X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome

Xlag Syndrome

Lissencephaly X-Linked With Ambiguous Genitalia

Lissencephaly, X-Linked, Type 2

Chromosome Xq26.3 Duplication Syndrome

Carney Complex Variant

Carney Complex

Carney Syndrome

Carney Complex, Type 1

Lamb Syndrome

Name Syndrome

Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome

Carney Complex - Trismus - Pseudocamptodactyly Syndrome

Carney Complex, Type 2

Car

Cnc1

Carney Myxoma-Endocrine Complex

Myxoma - Spotty Pigmentation - Endocrine Overactivity

Myxoma, Spotty Pigmentation, And Endocrine Overactivity

Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome

Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome

Carney Complex-Trismus-Pseudocamptodactyly Syndrome

CACOV

Multiple Endocrine Neoplasia

Men

Multiple Endocrine Adenomatosis

Multiple Endocrine Neoplasia Syndrome

Adenomatosis, Familial Endocrine

Endocrine Neoplasia, Multiple

Familial Endocrine Adenomatosis

Mea

Multiple Endocrine Neoplasms

Multiple Endocrine Neoplasia Type 1

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland

Endocrine Active Pituitary Adenoma

Secreting Pituitary Adenoma

Pituitary Adenoma, Functioning

Hyperpituitarism
Pituitary Infarct

Pituitary Infarction

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4

MEN4

Multiple Endocrine Neoplasia 4

Neoplasia, Endocrine, Multiple, Type Iv

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism

Hyperparathyroidism, Primary

Hyperparathyroidism Primary

Hypocalciuric Hypercalcemia, Familial, Type 1

Familial Benign Hypercalcemia

Familial Hyperparathyroidism

Parathyroid Enlargement

Pituitary Gland Disease

Pituitary Diseases

Pituitary Dysfunction

Pituitary Disease

Pituitary Deficiency

Pituitary Disorders

Tsh Producing Pituitary Tumor

Thyrotroph Adenoma

Tsh Producing Pituitary Tumour

Tsh Secreting Adenoma Of The Pituitary

Tsh Secreting Tumor Of Pituitary

Tsh Secreting Tumour Of Pituitary

Tsh-Secreting Pituitary Adenoma

Pituitary Thyrotrophic Adenoma

Tsh-Oma

Thyroid Stimulating Hormone-Secreting Pituitary Adenoma

Thyroid Stimulating Hormone-Producing Pituitary Tumor

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma

Corticotroph Adenoma

Corticotropinoma

Pituitary-Dependent Cushing'S Disease

Adrenal Gland Hyperfunction

Cushing Syndrome

Mccune-Albright Syndrome

Mass Syndrome

Polyostotic Fibrous Dysplasia

MAS

Fibrous Dysplasia Of Bone

Albright Syndrome

Mass Phenotype

Overlap Connective Tissue Disease

Mccune Albright Syndrome

Osteitis Fibrosa Disseminata

OCTD

Albright'S Disease

Pfd

Pofd

Albright'S Syndrome

Mccune-Albright Syndrome, Somatic, Mosaic

Albright'S Disease Of Bone

Albright'S Syndrome With Precocious Puberty

Albright-Mccune-Sternberg Syndrome

Albright-Sternberg Syndrome

Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty

Gonadotropin-Independent Female-Limited Sexual Precocity

Fibrous Dysplasia Polyostotic

Fibrous Dysplasia, Polyostotic

Endocrine Organ Benign Neoplasm
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta AIP VGNC VGNC:69759
Rattus norvegicus AIP RGD RGD:628619
Felis catus AIP VGNC VGNC:59703
Canis familiaris AIP VGNC VGNC:37741
Mus musculus AIP MGD MGI:109622
Bos taurus AIP VGNC VGNC:25767
Others AIP NCBI
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