2. Gene
  3. Zc3h12a - zinc finger CCCH type containing 12A Gene

Zc3h12a - zinc finger CCCH type containing 12A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Reg1; MCPIP; Mcpip1; MCPIP-1

基因 ID: 230738 | 基因类型: protein coding

关于 Zc3h12a

功能概要

Enables RNA binding activity; ribonuclease activity; and ribosome binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of gene expression; and negative regulation of intracellular signal transduction. Located in nucleus and rough endoplasmic reticulum. Is extrinsic component of endoplasmic reticulum membrane. Used to study primary biliary cholangitis. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Apr 2022]

Zc3h12a 基因产物(1)

mRNA Protein Name
NM_153159.2 NP_694799.1 endoribonuclease ZC3H12A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA endonuclease activity IDA
IDA: 通过直接分析推断
22055188 MGI
enables RNA exonuclease activity IDA
IDA: 通过直接分析推断
19322177 MGI
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
23185455 MGI
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
19322177 MGI
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
23185455 MGI
enables mRNA binding EXP
EXP: 通过实验结果推断
26927947 MGI
enables nuclease activity IMP
IMP: 通过突变表型推断
25282160 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22037600 MGI
enables ribosome binding IDA
IDA: 通过直接分析推断
26255671 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
19322177 MGI
involved in T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
23185455 MGI
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
25282160 MGI
involved in cellular response to chemokine IDA
IDA: 通过直接分析推断
19666473 MGI
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
21971051 MGI
involved in cellular response to ionomycin IDA
IDA: 通过直接分析推断
23185455 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
19322177 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
21971051 MGI
involved in cellular response to sodium arsenite IDA
IDA: 通过直接分析推断
21971051 MGI
involved in mRNA catabolic process IDA
IDA: 通过直接分析推断
26000482 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: 通过突变表型推断
25282160 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of cardiac muscle contraction IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
18178554 MGI
involved in negative regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of muscle cell apoptotic process IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
21971051 MGI
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
21616078 MGI
involved in negative regulation of type II interferon production IDA
IDA: 通过直接分析推断
21616078 MGI
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
22739135 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
21971051 MGI
involved in positive regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
19666473 MGI
involved in positive regulation of lipid storage IMP
IMP: 通过突变表型推断
22739135 MGI
involved in positive regulation of mRNA catabolic process IDA
IDA: 通过直接分析推断
19322177 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19666473 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19322177 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16574901 MGI
located in rough endoplasmic reticulum IDA
IDA: 通过直接分析推断
26255671 MGI
located in rough endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
26000482 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endoribonuclease ZC3H12A

MCP-1 treatment-induced protein

MCP-induced protein 1

bifunctional endoribonuclease and deubiquitinase ZC3H12A

monocyte chemotactic protein-induced protein 1

regnase-1

ribonuclease ZC3H12A

zinc finger CCCH domain-containing protein 12A

Zc3h12a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Zc3h12a Q5D1E7 IKBKB Homo sapiens O14920
Anti Tag CoIP
22037600
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15986 ZC3H12A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Zc3h12a NCBI NCBI:80149
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z