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  2. SP4 - Sp4 transcription factor Gene

SP4 - Sp4 transcription factor Gene

中文名称:Sp4 转录因子

种属: Homo sapiens

同用名: HF1B; SPR-1

基因 ID: 6671 | 基因类型: protein coding

关于 SP4

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:21,428,083-21,514,822 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 3.6), thyroid (RPKM 3.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种转录因子,可以结合多种基因的 GC 启动子区域,包括光感受器信号转导系统的基因。编码的蛋白质与转录因子 SP1 一样与启动子 CpG 岛中的相同位点结合,尽管与 SP1 相比其表达受到更多限制。该基因可能与躁郁症和精神分裂症有关。[RefSeq 提供,2016 年 5 月]

The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]

SP4 基因产物(3)

mRNA Protein Name
NM_001326542.2 NP_001313471.1 transcription factor Sp4 isoform 2
NM_001326543.2 NP_001313472.1 transcription factor Sp4 isoform 3
NM_003112.5 NP_003103.2 transcription factor Sp4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24722188 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23332764 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive effect regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7559627 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12560508 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SP4 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (663 - 690)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (694 - 716)

  • 0
  • 200
  • 400
  • 600
  • 784 a.a.
蛋白主名 其他名称

transcription factor Sp4

SP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SP4 Q02446 PRR20C Homo sapiens P86479
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 PRR20C Homo sapiens P86479
Y2H Array
25416956
种属内
SP4 Q02446 a0a024r5s0_human Homo sapiens EBI-10188461
Validated Y2H
25416956
种属内
SP4 Q02446 CIB3 Homo sapiens Q96Q77
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
种属内
SP4 Q02446 a0a024r5s0_human Homo sapiens EBI-10188461
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 CIB3 Homo sapiens Q96Q77
Validated Y2H
25416956
种属内
SP4 Q02446 CIB3 Homo sapiens Q96Q77
Y2H Array
25416956
种属内
SP4 Q02446 FOXP2 Homo sapiens Q75MZ5
Validated Y2H
25416956
种属内
SP4 Q02446 FOXP2 Homo sapiens Q75MZ5
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 LOC730441 Homo sapiens Q4G0S1
Validated Y2H
25416956
种属内
SP4 Q02446 PNKP Homo sapiens Q96T60
Validated Y2H
32296183
种属内
SP4 Q02446 POU2F1 Homo sapiens P14859-6
Y2H Array
32296183
种属内
SP4 Q02446 POU2F1 Homo sapiens P14859-6
Y2H Prey Pooling
32296183
种属内
SP4 Q02446 NRF1 Homo sapiens Q16656-4
Validated Y2H
32296183
种属内
SP4 Q02446 NFYC Homo sapiens Q13952-2
Y2H Array
32296183
种属内
SP4 Q02446 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
种属内
SP4 Q02446 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
种属内
SP4 Q02446 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
种属内
SP4 Q02446 SPANXN3 Homo sapiens Q5MJ09
Validated Y2H
32296183
种属内
SP4 Q02446 PRR20D Homo sapiens P86480
Y2H Array
32296183
种属内
SP4 Q02446 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
种属内
SP4 Q02446 NRF1 Homo sapiens Q16656
Validated Y2H
25416956
种属内
SP4 Q02446 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
种属内
SP4 Q02446 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
种属内
SP4 Q02446 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
种属内
SP4 Q02446 POU2F1 Homo sapiens P14859
Y2H Array
25416956
种属内
SP4 Q02446 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
SP4 Q02446 LMO3 Homo sapiens Q8TAP4
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 LMO3 Homo sapiens Q8TAP4
Y2H Array
25416956
种属内
SP4 Q02446 COL8A1 Homo sapiens P27658
Y2H Prey Pooling
25416956
种属内
SP4 Q02446 COL8A1 Homo sapiens P27658
Y2H Array
25416956
种属内
SP4 Q02446 ADAM15 Homo sapiens Q13444
Validated Y2H
25416956
种属内
SP4 Q02446 ADAM15 Homo sapiens Q13444
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Spastic Paraplegia 5a, Autosomal Recessive

SPG5A

Hereditary Spastic Paraplegia 5a

Autosomal Recessive Spastic Paraplegia 5a

Autosomal Recessive Spastic Paraplegia Type 5a

Spastic Paraplegia 5a

Spastic Paraplegia Type 5a

Spastic Paraplegia Type 5a, Recessive

Autosomal Recessive Spastic Paraplegia

Spastic Paraplegia-5a

Paraplegia, Spastic, Autosomal Recessive, Type 5a

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SP4 VGNC VGNC:80723
Macaca mulatta SP4 VGNC VGNC:77847
Bos taurus SP4 VGNC VGNC:35155
Rattus norvegicus SP4 RGD RGD:3741
Mus musculus SP4 MGD MGI:107595
Canis familiaris SP4 VGNC VGNC:46687
Others SP4 NCBI