2. Gene
  3. LMO3 - LIM domain only 3 Gene

LMO3 - LIM domain only 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LIM 域只有 3

种属: Homo sapiens

同用名: RBTN3; RHOM3; RBTNL2; Rhom-3

基因 ID: 55885 | 基因类型: protein coding

关于 LMO3

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:16,548,372-16,610,174 (from NCBI)

This gene has 34 transcripts (splice variants), 205 orthologues and 20 paralogues. Biased expression in brain (RPKM 41.7), lung (RPKM 13.9) and 7 other tissues.

功能概要

该基因编码的蛋白质属于富含半胱氨酸的 LIM 结构域致癌基因的菱形蛋白家族。该基因主要在大脑中表达。据报道，11 号染色体上的相关家族成员 LMO1 和 LMO2 参与了 T 细胞白血病的染色体易位。已发现该基因的许多选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

LMO3 基因产物(7)

mRNA Protein Name
NM_001001395.2 NP_001001395.1 LIM domain only protein 3 isoform 1
NM_001243609.1 NP_001230538.1 LIM domain only protein 3 isoform 1
NM_001243610.1 NP_001230539.1 LIM domain only protein 3 isoform 1
NM_001243611.1 NP_001230540.1 LIM domain only protein 3 isoform 2
NM_001243612.1 NP_001230541.1 LIM domain only protein 3 isoform 3
NM_001243613.1 NP_001230542.1 LIM domain only protein 3 isoform 4
NM_018640.5 NP_061110.2 LIM domain only protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
23823477 GOA
involved in positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
23823477 GOA
involved in positive regulation of glucocorticoid receptor signaling pathway IDA
IDA: 通过直接分析推断
23823477 GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: 通过直接分析推断
23823477 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23823477 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LMO3 蛋白结构

LIM

LIM: LIM domain (13 - 71)

LIM

LIM: LIM domain (77 - 132)

  • 0
  • 100
  • 145 a.a.
蛋白主名 其他名称

LIM domain only protein 3

LIM domain only 3 (rhombotin-like 2)

LMO3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LMO3 Q8TAP4 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra LMO3 Q8TAP4 NUTM1 Homo sapiens Q86Y26
Y2H Array
25416956
Intra LMO3 Q8TAP4 SP4 Homo sapiens Q02446
Validated Y2H
25416956
Intra LMO3 Q8TAP4 FOS Homo sapiens Q6FG41
Validated Y2H
25416956
Intra LMO3 Q8TAP4 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
31515488
Intra LMO3 Q8TAP4 FBLIM1 Homo sapiens Q8WUP2
Y2H Prey Pooling
25416956
Intra LMO3 Q8TAP4 FBLIM1 Homo sapiens Q8WUP2
Validated Y2H
25416956
Intra LMO3 Q8TAP4 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
25416956
Intra LMO3 Q8TAP4 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
25416956
Intra LMO3 Q8TAP4 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra LMO3 Q8TAP4 LDB1 Homo sapiens Q86U70
Anti Tag CoIP
33961781
Intra LMO3 Q8TAP4 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra LMO3 Q8TAP4 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra LMO3 Q8TAP4 FAM131C Homo sapiens Q96AQ9
Y2H Prey Pooling
25416956
Intra LMO3 Q8TAP4 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra LMO3 Q8TAP4 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra LMO3 Q8TAP4 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra LMO3 Q8TAP4 IKZF1 Homo sapiens Q13422
Y2H Array
25416956
Intra LMO3 Q8TAP4 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra LMO3 Q8TAP4 SAMD3 Homo sapiens Q8N6K7
Validated Y2H
25416956
Intra LMO3 Q8TAP4 SAMD3 Homo sapiens Q8N6K7
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07719 LMO3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LMO3 MGD MGI:102810
Bos taurus LMO3 VGNC VGNC:30935
Macaca mulatta LMO3 VGNC VGNC:100072
Felis catus LMO3 VGNC VGNC:68071
Canis familiaris LMO3 VGNC VGNC:42723
Rattus norvegicus LMO3 RGD RGD:1561357
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