LDB1 - LIM domain binding 1 Gene

中文名称：LIM 域绑定 1

种属: Homo sapiens

同用名: NLI; CLIM2; LDB-1; CLIM-2

基因 ID: 8861 | 基因类型: protein coding

关于 LDB1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,102,088-102,121,442 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 42.1), ovary (RPKM 38.8) and 25 other tissues.

功能概要

启用 LIM 域绑定活动； RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性；和酶结合活性。参与转录的负调控、DNA 模板化和 RNA 聚合酶 II 对转录的正调控。位于染色质中。 β-连环蛋白-TCF 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables LIM domain binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and Enzyme binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in chromatin. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

LDB1 基因产物(3)

mRNA	Protein	Name
NM_001113407.3	NP_001106878.1	LIM domain-binding protein 1 isoform 1
NM_001321612.2	NP_001308541.1	LIM domain-binding protein 1 isoform 2
NM_003893.5	NP_003884.1	LIM domain-binding protein 1 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	32417234	GOA
enables LIM domain binding	IPI IPI: 通过物理相互作用推断	12792813	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16314316	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	23382074	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12792813	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10767331	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	20855495	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of beta-catenin-TCF complex	IDA IDA: 通过直接分析推断	28296634	GOA
located in chromatin	IDA IDA: 通过直接分析推断	20855495	GOA
part of transcription regulator complex	IDA IDA: 通过直接分析推断	16314316	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LDB1 蛋白结构

LIM_bind

0
100
200
300
411 a.a.

蛋白主名

其他名称

LIM domain-binding protein 1

LIM domain-binding factor CLIM2

LDB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LDB1	Q86U70	LMX1B	Homo sapiens	O60663-2	Validated Y2H	25416956
种属内	LDB1	Q86U70	LHX6	Homo sapiens	Q9UPM6	Y2H Prey Pooling	25416956
种属内	LDB1	Q86U70	LHX2	Homo sapiens	P50458	Y2H Array	20211142
种属内	LDB1	Q86U70	SYNGAP1	Homo sapiens	Q96PV0	Anti Bait CoIP	37207277
种属内	LDB1	Q86U70	LMO4	Homo sapiens	P61968	Y2H Prey Pooling	25416956
种属内	LDB1	Q86U70	LMO4	Homo sapiens	P61968	Y2H Array	25416956
种属内	LDB1	Q86U70	LMX1B	Homo sapiens	O60663	Y2H	12792813
种属内	LDB1	Q86U70	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
种属内	LDB1	Q86U70	LMO2	Homo sapiens	P25791	Y2H Array	25416956
种属内	LDB1	Q86U70	LMO3	Homo sapiens	Q8TAP4	Y2H Pooling	16189514
种属内	LDB1	Q86U70	LMO3	Homo sapiens	Q8TAP4	Y2H Array	20211142
种属内	LDB1	Q86U70	SSBP4	Homo sapiens	Q9BWG4	Y2H Pooling	16189514
种属内	LDB1	Q86U70	SSBP2	Homo sapiens	P81877	Y2H Pooling	16189514
种属内	LDB1	Q86U70	LHX8	Homo sapiens	Q68G74	Validated Y2H	25416956
种属内	LDB1	Q86U70	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	25416956
种属内	LDB1	Q86U70	LMO1	Homo sapiens	P25800	Y2H Array	25416956
种属内	LDB1	Q86U70	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
种属内	LDB1	Q86U70	LMO1	Homo sapiens	P25800	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nail-Patella Syndrome

Turner-Kieser Syndrome	Onychoosteodysplasia
Fong Disease	NPS
Hereditary Onycho-Osteodysplasia	Nps1
Hereditary Onychoostedysplasia	Iliac Horn Syndrome
Nail Patella Syndrome	Turner-Kiser Syndrome
Arthro-Onychodysplasia	Nps 1
Osteo-Onychodysplasia	Hereditary Osteo-Onychodysplasia
Osterreicher Syndrome	Pelvic Horn Syndrome
Österreicher-Turner Syndrome	Nps - [Nail-Patella Syndrome]
Hood - [Hereditary Onycho-Osteodysplasia] Syndrome

Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Neurogenic Bowel

Quadriplegia

Tetraplegia

Tetraplegias

Plexopathy

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin	Delta-Beta-Thalassemia
Delta-Beta Thalassemia	Delta Beta-Thalassemia
HBFQTL1	Hemoglobin F, Hereditary Persistence Of
Hpfh	Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related
Hemoglobin, Fetal, Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Thalassemia
Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]	Fetal Haemoglobin
Persistence Of Fetal Haemoglobin	Persistent Haemoglobin F

Hemoglobinopathy

Hemoglobinopathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07568	LDB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	LDB1	VGNC	VGNC:68027
Macaca mulatta	LDB1	VGNC	VGNC:74245
Canis familiaris	LDB1	VGNC	VGNC:42618
Bos taurus	LDB1	VGNC	VGNC:55957
Mus musculus	LDB1	MGD	MGI:894762
Rattus norvegicus	LDB1	RGD	RGD:1310359

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LDB1 - LIM domain binding 1 Gene

关于 LDB1

功能概要

LDB1 基因产物(3)

LDB1 蛋白结构

LDB1 蛋白互作信息

关联疾病

直系同源

热门区域

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LDB1 - LIM domain binding 1 Gene

关于 LDB1

功能概要

LDB1 基因产物(3)

LDB1 蛋白结构

LDB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z