2. Gene
  3. LHX8 - LIM homeobox 8 Gene

LHX8 - LIM homeobox 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LIM 同源框 8

种属: Homo sapiens

同用名: LHX7

基因 ID: 431707 | 基因类型: protein coding

关于 LHX8

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:75,128,434-75,199,454 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 20 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是 LIM 同源框蛋白质家族的成员，参与各种组织类型的模式化和分化。除了 DNA 结合同源结构域之外，这些蛋白质还包含两个串联重复的富含半胱氨酸的双锌指基序，称为 LIM 结构域。该家族成员是一种转录因子，在牙齿形态发生中发挥作用。它还参与卵子发生和神经元分化。该基因是腭裂的候选基因，也与牙瘤的形成有关。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2012 年 1 月]

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

LHX8 基因产物(2)

mRNA Protein Name
NM_001001933.1 NP_001001933.1 LIM/homeobox protein Lhx8 isoform 1
NM_001256114.2 NP_001243043.1 LIM/homeobox protein Lhx8 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LHX8 蛋白结构

LIM

LIM: LIM domain (75 - 131)

LIM

LIM: LIM domain (136 - 190)

Homeobox

Homeobox: Homeobox domain (226 - 282)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
蛋白主名 其他名称

LIM/homeobox protein Lhx8

LIM-homeodomain protein Lhx8

LHX8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LHX8 Q68G74 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
种属内
LHX8 Q68G74 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
种属内
LHX8 Q68G74 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
LHX8 Q68G74 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
LHX8 Q68G74 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
LHX8 Q68G74 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
种属内
LHX8 Q68G74 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
种属内
LHX8 Q68G74 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
种属内
LHX8 Q68G74 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
种属内
LHX8 Q68G74 FOXN1 Homo sapiens O15353
Y2H Array
32296183
种属内
LHX8 Q68G74 FOXN1 Homo sapiens O15353
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
种属内
LHX8 Q68G74 EFS Homo sapiens O43281-2
Y2H Array
32296183
种属内
LHX8 Q68G74 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 FIGLA Homo sapiens Q6QHK4
Validated Y2H
32296183
种属内
LHX8 Q68G74 FIGLA Homo sapiens Q6QHK4
Complementation
32296183
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70-2
Validated Y2H
32296183
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70-2
Y2H Array
32296183
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70-2
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 ATF6B Homo sapiens Q96QL7
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 ATF6B Homo sapiens Q96QL7
Validated Y2H
32296183
种属内
LHX8 Q68G74 ATF6B Homo sapiens Q96QL7
Y2H Array
32296183
种属内
LHX8 Q68G74 TSC1 Homo sapiens Q86WV8
Validated Y2H
32814053
种属内
LHX8 Q68G74 TSC1 Homo sapiens Q86WV8
Y2H Array
32814053
种属内
LHX8 Q68G74 TSC1 Homo sapiens Q86WV8
Y2H Pooling
32814053
种属内
LHX8 Q68G74 SCYL3 Homo sapiens Q8IZE3
Y2H Prey Pooling
25416956
种属内
LHX8 Q68G74 SCYL3 Homo sapiens Q8IZE3
Validated Y2H
25416956
种属内
LHX8 Q68G74 SCYL3 Homo sapiens Q8IZE3
Y2H Array
25416956
种属内
LHX8 Q68G74 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
种属内
LHX8 Q68G74 TBC1D1 Homo sapiens Q86TI0
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 TBC1D1 Homo sapiens Q86TI0
Y2H Array
32296183
种属内
LHX8 Q68G74 TBC1D1 Homo sapiens Q86TI0
Validated Y2H
32296183
种属内
LHX8 Q68G74 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
种属内
LHX8 Q68G74 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
种属内
LHX8 Q68G74 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
种属内
LHX8 Q68G74 LDB2 Homo sapiens O43679
Y2H Prey Pooling
32296183
种属内
LHX8 Q68G74 LDB2 Homo sapiens O43679
Y2H Array
32296183
种属内
LHX8 Q68G74 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
LHX8 Q68G74 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
LHX8 Q68G74 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
LHX8 Q68G74 CCT5 Homo sapiens P48643
Y2H Array
32814053
种属内
LHX8 Q68G74 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
种属内
LHX8 Q68G74 CCT5 Homo sapiens P48643
Validated Y2H
32814053
种属内
LHX8 Q68G74 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
LHX8 Q68G74 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
LHX8 Q68G74 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
LHX8 Q68G74 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
LHX8 Q68G74 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
LHX8 Q68G74 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70
Y2H Array
25416956
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70
BioID
35140242
种属内
LHX8 Q68G74 LDB1 Homo sapiens Q86U70
Affinity Chrom
35140242
种属内
LHX8 Q68G74 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
LHX8 Q68G74 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
LHX8 Q68G74 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
LHX8 Q68G74 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
种属内
LHX8 Q68G74 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
种属内
LHX8 Q68G74 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
种属内
LHX8 Q68G74 GINS4 Homo sapiens Q9BRT9
Validated Y2H
32296183
种属内
LHX8 Q68G74 GRN Homo sapiens P28799
Y2H Array
32814053
种属内
LHX8 Q68G74 GRN Homo sapiens P28799
Validated Y2H
32814053
种属内
LHX8 Q68G74 GRN Homo sapiens P28799
Y2H Pooling
32814053
种属内
LHX8 Q68G74 KLF3 Homo sapiens P57682
Validated Y2H
25416956
种属内
LHX8 Q68G74 KLF3 Homo sapiens P57682
Y2H Array
25416956
种属内
LHX8 Q68G74 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
种属内
LHX8 Q68G74 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属内
LHX8 Q68G74 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
种属内
LHX8 Q68G74 PEX1 Homo sapiens O43933
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Odontoma
Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2

Hsan2

HSAN2A

Morvan Disease

Hereditary Sensory And Autonomic Neuropathy Type Ii

Neurogenic Acroosteolysis

Hsan Iia

Hsn2a

Hsn Iia

Neuropathy, Progressive Sensory, Of Children

Neuropathy, Congenital Sensory

Neuropathy, Hereditary Sensory And Autonomic, Type Ii

Hereditary Sensory And Autonomic Neuropathy Type 2a

Hereditary Sensory And Autonomic Neuropathy Type Iia

Hsanii

Congenital Sensory Neuropathy

Hsan Type Ii

Morvan Syndrome

Neuropathy, Hereditary Sensory And Autonomic, Type 2a

Morvan'S Disease

Neuropathy, Hereditary Sensory, Type Iia

Acroosteolysis, Neurogenic

Acroosteolysis, Giaccai Type

Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive

Hereditary Sensory Autonomic Neuropathy Type 2

Giaccai Type Acroosteolysis

Hereditary Sensory Neuropathy Type 2

Hereditary Sensory Radicular Neuropathy, Recessive Form

Hsan2b

Hsan2c

Hsan2d

Hsn Type Ii

Autosomal Recessive Sensory Radicular Neuropathy

Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome

Morvan Fibrillary Chorea

Neuropathy, Hereditary Sensory And Autonomic, 2a

Acroosteolysis Giaccai Type

Hereditary Sensory Neuropathy Type Iia

Hereditary Sensory Radicular Neuropathy Autosomal Recessive

Progressive Sensory Neuropathy Of Children

Neuropathy Congenital Sensory

Charcot-Marie-Tooth Disease

Neuropathy, Sensory And Autonomic, Hereditary, Type Iia

Hereditary Sensory Autonomic Neuropathy, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Sensory Neuropathy, Hereditary

Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Geotrichosis
Cerebral Hemisphere Lipoma

Lipoma Of The Cerebral Hemisphere
Corpus Callosum Lipoma

Lipoma Of The Corpus Callosum

Lipoma Of Corpus Callosum
Cleft Lip

Cheiloschisis

Labium Leporinum

Cleft Lip, Unilateral, Complete

Complete Unilateral Cleft Lip

Hare Lip

Congenital Fissure Of Lip

Isolated Cleft Lip

Cleft Lip Without Cleft Palate

Cleft Lip Without Cleft Palate, Unilateral

Isolated Cleft Lip, Unilateral

Cleft Lip Without Cleft Palate, Bilateral

Isolated Cleft Lip, Bilateral
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Central Nervous System Lipoma

Lipoma Of The Cns
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Van Der Woude Syndrome

Lip-Pit Syndrome

Vws

Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip

Vdws

Lps

Lip Pit Syndrome

Cleft Lip/Palate With Mucous Cysts Of Lower Lip

Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Orofacial Cleft

Cleft, Orofacial
Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07637 LHX8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LHX8 MGD MGI:1096343
Canis familiaris LHX8 VGNC VGNC:42668
Rattus norvegicus LHX8 RGD RGD:1308749
Bos taurus LHX8 VGNC VGNC:30877
Felis catus LHX8 VGNC VGNC:63225
Macaca mulatta LHX8 VGNC VGNC:74144
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