FIGLA - folliculogenesis specific bHLH transcription factor Gene

中文名称：卵泡发生特异性 bHLH 转录因子

种属: Homo sapiens

同用名: POF6; BHLHC8; FIGALPHA

基因 ID: 344018 | 基因类型: protein coding

关于 FIGLA

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,777,310-70,790,643 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues, 13 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码一种在出生后卵母细胞特异性基因表达中起作用的蛋白质。该蛋白质是一种基本的螺旋-环-螺旋转录因子，可调节多个卵母细胞特异性基因，包括参与卵泡发生的基因和编码透明带的基因。该基因的突变导致 6 型卵巢早衰。[RefSeq 提供，2009 年 9 月]

This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

FIGLA 基因产物(1)

mRNA	Protein	Name
NM_001004311.3	NP_001004311.2	factor in the germline alpha

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to E-box binding	IPI IPI: 通过物理相互作用推断	15044608	GOA
enables bHLH transcription factor binding	IPI IPI: 通过物理相互作用推断	15044608	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of transcription regulator complex	IDA IDA: 通过直接分析推断	15044608	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FIGLA 蛋白结构

HLH

0
100
200
219 a.a.

蛋白主名

其他名称

factor in the germline alpha

class C basic helix-loop-helix protein 8

FIGLA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FIGLA	Q6QHK4	LHX6	Homo sapiens	Q9UPM6	Validated Y2H	32296183
Intra	FIGLA	Q6QHK4	LHX6	Homo sapiens	Q9UPM6	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	LHX6	Homo sapiens	Q9UPM6	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	FIGLA	Q6QHK4	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	FIGLA	Q6QHK4	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	TCF23	Homo sapiens	Q7RTU1	Validated Y2H	32296183
Intra	FIGLA	Q6QHK4	TCF23	Homo sapiens	Q7RTU1	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	TCF23	Homo sapiens	Q7RTU1	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	MYOD1	Homo sapiens	P15172	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	MYOD1	Homo sapiens	P15172	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	32296183
Intra	FIGLA	Q6QHK4	LHX8	Homo sapiens	Q68G74	Y2H Array	32296183
Intra	FIGLA	Q6QHK4	LHX8	Homo sapiens	Q68G74	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Premature Ovarian Failure 6

POF6	Ovarian Failure, Premature, Type 6

Genetic Non-Acquired Premature Ovarian Failure

Ovarian Dysgenesis 2

Premature Ovarian Failure 4	ODG2
Ovarian Dysgenesis, Hypergonadotropic, X-Linked	Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis
Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis	X-Linked Hypergonadotropic Ovarian Dysgenesis
POF4	Dysgenesis, Ovarian, Type 2

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Amenorrhea

Absence Of Menstruation

Amenia

Hermaphroditism

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04945	FIGLA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FIGLA	VGNC	VGNC:72563
Canis familiaris	FIGLA	VGNC	VGNC:54149
Mus musculus	FIGLA	MGD	MGI:1349421
Bos taurus	FIGLA	VGNC	VGNC:29009
Felis catus	FIGLA	VGNC	VGNC:80099
Rattus norvegicus	FIGLA	RGD	RGD:1564754

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FIGLA - folliculogenesis specific bHLH transcription factor Gene

关于 FIGLA

功能概要

FIGLA 基因产物(1)

FIGLA 蛋白结构

FIGLA 蛋白互作信息

关联疾病

直系同源

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FIGLA - folliculogenesis specific bHLH transcription factor Gene

关于 FIGLA

功能概要

FIGLA 基因产物(1)

FIGLA 蛋白结构

FIGLA 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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F

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H

J

L

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Q

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