1. Gene
  2. SCYL3 - SCY1 like pseudokinase 3 Gene

SCYL3 - SCY1 like pseudokinase 3 Gene

中文名称:SCY1 样假激酶 3

种属: Homo sapiens

同用名: PACE1; PACE-1

基因 ID: 57147 | 基因类型: protein coding

关于 SCYL3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,849,631-169,894,268 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 4.6), testis (RPKM 4.3) and 25 other tissues.

功能概要

该基因编码一种具有激酶结构域和四个 HEAT 重复序列的蛋白质。编码的蛋白质与埃兹蛋白 (一种 ERM 蛋白) 的 C 末端结构域相互作用,并可能在细胞粘附和迁移中发挥作用。可变剪接导致编码多个亚型的多个转录本变体。[RefSeq 提供,2012 年 6 月]

This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

SCYL3 基因产物(2)

mRNA Protein Name
NM_020423.7 NP_065156.5 protein-associating with the carboxyl-terminal domain of ezrin isoform 1
NM_181093.4 NP_851607.2 protein-associating with the carboxyl-terminal domain of ezrin isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables kinase activity IDA
IDA: 通过直接分析推断
12651155 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12651155 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12651155 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12651155 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
12651155 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SCYL3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (36 - 236)

  • 0
  • 200
  • 400
  • 600
  • 742 a.a.
蛋白主名 其他名称

protein-associating with the carboxyl-terminal domain of ezrin

SCY1-like 3

SCYL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SCYL3 Q8IZE3 EZR Homo sapiens P15311
Confocal
12651155
种属内
SCYL3 Q8IZE3 EZR Homo sapiens P15311
Y2H
12651155
种属内
SCYL3 Q8IZE3 EZR Homo sapiens P15311
Pull Down
32707033
种属内
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
种属内
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
种属内
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757
Y2H Array
25416956
种属内
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
25416956
种属内
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8
Y2H Array
25416956
种属内
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Afferent Loop Syndrome

Afferent Limb Syndrome

Facial Neuralgia
Herpes Zoster Oticus

Nervus Intermedius Neuralgia

Ramsay Hunt Syndrome Type 2

Geniculate Herpes Zoster

Geniculate Neuralgia

Herpes Zoster Auricularis

Herpetic Geniculate Ganglionitis

Ramsay Hunt Syndrome Type Ii

Ramsey Hunt Syndrome

Facial Nerve Palsy Due To Vzv

Facial Nerve Palsy Due To Herpes Zoster Infection

Facial Nerve Paralysis Due To Vzv

Hunt Syndrome

Hunt'S Syndrome

Ramsay Hunt Syndrome

Myoclonus And Ataxia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SCYL3 MGD MGI:1921385
Rattus norvegicus SCYL3 RGD RGD:1308992
Canis familiaris SCYL3 VGNC VGNC:45940
Bos taurus SCYL3 VGNC VGNC:34376
Macaca mulatta SCYL3 VGNC VGNC:77053
Felis catus SCYL3 VGNC VGNC:64942
Others SCYL3 NCBI