LDB2 - LIM domain binding 2 Gene

中文名称：LIM 域绑定 2

种属: Homo sapiens

同用名: LDB1; CLIM1; LDB-2

基因 ID: 9079 | 基因类型: protein coding

关于 LDB2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:16,501,541-16,898,645 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 25.9), fat (RPKM 24.8) and 23 other tissues.

功能概要

该基因编码的蛋白质属于 LIM 结构域结合家族。该家族成员的特征在于保守的核定位序列、氨基末端同源二聚化结构域和羧基末端 LIM 相互作用结构域。这些蛋白质充当衔接分子以允许组装转录调节复合物。遗传关联研究表明该基因在孔源性视网膜脱离和冠状动脉疾病中的功能。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

LDB2 基因产物(4)

mRNA	Protein	Name
NM_001130834.3	NP_001124306.1	LIM domain-binding protein 2 isoform b
NM_001290.5	NP_001281.1	LIM domain-binding protein 2 isoform a
NM_001304434.2	NP_001291363.1	LIM domain-binding protein 2 isoform c
NM_001304435.2	NP_001291364.1	LIM domain-binding protein 2 isoform d

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15231748	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	9853615	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LDB2 蛋白结构

LIM_bind

0
100
200
300
373 a.a.

蛋白主名

其他名称

LIM domain-binding protein 2

LIM binding domain 2

LDB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LDB2	O43679	GGACT	Homo sapiens	Q9BVM4	Validated Y2H	32296183
Intra	LDB2	O43679	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	LDB2	O43679	EGLN3	Homo sapiens	Q9H6Z9	Validated Y2H	32296183
Intra	LDB2	O43679	LMO2	Homo sapiens	P25791-3	Validated Y2H	32296183
Intra	LDB2	O43679	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	LDB2	O43679	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	LDB2	O43679	TSNAX	Homo sapiens	Q99598	Y2H	18330356
Intra	LDB2	O43679	LMO4	Homo sapiens	P61968	Y2H	15231748
Intra	LDB2	O43679	LMO4	Homo sapiens	P61968	Y2H	18330356
Intra	LDB2	O43679	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
Intra	LDB2	O43679	EXOC3L1	Homo sapiens	Q86VI1	Validated Y2H	32296183
Intra	LDB2	O43679	SSBP3	Homo sapiens	Q9BWW4	Y2H	18330356
Intra	LDB2	O43679	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	20211142
Intra	LDB2	O43679	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	LDB2	O43679	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	LDB2	O43679	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	LDB2	O43679	MYDGF	Homo sapiens	Q969H8	Validated Y2H	32296183
Intra	LDB2	O43679	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	LDB2	O43679	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	LDB2	O43679	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	LDB2	O43679	DGCR6L	Homo sapiens	Q9BY27	Validated Y2H	32296183
Intra	LDB2	O43679	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
Intra	LDB2	O43679	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	LDB2	O43679	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin	Delta-Beta-Thalassemia
Delta-Beta Thalassemia	Delta Beta-Thalassemia
HBFQTL1	Hemoglobin F, Hereditary Persistence Of
Hpfh	Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related
Hemoglobin, Fetal, Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Thalassemia
Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]	Fetal Haemoglobin
Persistence Of Fetal Haemoglobin	Persistent Haemoglobin F

Hemoglobinopathy

Hemoglobinopathies

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07569	LDB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LDB2	MGD	MGI:894670
Bos taurus	LDB2	VGNC	VGNC:30822
Rattus norvegicus	LDB2	RGD	RGD:1307921
Macaca mulatta	LDB2	VGNC	VGNC:74246
Canis familiaris	LDB2	VGNC	VGNC:42619
Felis catus	LDB2	VGNC	VGNC:68028

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