2. Gene
  3. LHX2 - LIM homeobox 2 Gene

LHX2 - LIM homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LIM 同源框 2

种属: Homo sapiens

同用名: LH2; hLhx2

基因 ID: 9355 | 基因类型: protein coding

关于 LHX2

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,011,768-124,033,301 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.5), placenta (RPKM 1.0) and 2 other tissues.

功能概要

该基因编码属于一个大蛋白质家族的蛋白质，其成员携带 LIM 结构域，这是一个独特的富含半胱氨酸的锌结合结构域。所编码的蛋白质可作为转录调节剂发挥作用。该蛋白质可以重现或挽救由相关蛋白质引起的果蝇表型，表明进化过程中的功能守恒。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]

LHX2 基因产物(1)

mRNA Protein Name
NM_004789.4 NP_004780.3 LIM/homeobox protein Lhx2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LHX2 蛋白结构

LIM

LIM: LIM domain (53 - 110)

LIM

LIM: LIM domain (115 - 170)

Homeobox

Homeobox: Homeobox domain (267 - 323)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

LIM/homeobox protein Lhx2

LIM HOX gene 2

LHX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LHX2 P50458 LGALSL Homo sapiens Q3ZCW2
Validated Y2H
32296183
Intra LHX2 P50458 ZNF511 Homo sapiens Q8NB15
Validated Y2H
32296183
Intra LHX2 P50458 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra LHX2 P50458 TRAPPC2L Homo sapiens Q9UL33-2
Validated Y2H
32296183
Intra LHX2 P50458 TRAPPC2L Homo sapiens Q9UL33-2
Y2H Array
32296183
Intra LHX2 P50458 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra LHX2 P50458 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70-2
Validated Y2H
32296183
Intra LHX2 P50458 ZFP42 Homo sapiens Q96MM3
Validated Y2H
32296183
Intra LHX2 P50458 POU4F2 Homo sapiens Q12837
Validated Y2H
32296183
Intra LHX2 P50458 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra LHX2 P50458 TCP11L1 Homo sapiens Q9NUJ3
Validated Y2H
32296183
Intra LHX2 P50458 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
32296183
Intra LHX2 P50458 OSMR Homo sapiens Q99650
Validated Y2H
32296183
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70
Affinity Chrom
35140242
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70
BioID
35140242
Intra LHX2 P50458 FLYWCH1 Homo sapiens Q4VC44
Validated Y2H
32296183
Intra LHX2 P50458 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra LHX2 P50458 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra LHX2 P50458 TLK1 Homo sapiens Q9UKI8
Validated Y2H
32296183
Intra LHX2 P50458 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra LHX2 P50458 BEND2 Homo sapiens Q8NDZ0
Validated Y2H
32296183
Intra LHX2 P50458 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
Coloboma Of Macula

Coloboma

Congenital Ocular Coloboma

Microphthalmia, Isolated, With Coloboma

Agenesis Of Macula

Hereditary Macular Coloboma

Ocular Coloboma

Coloboma Of Eye

Macular Coloboma

Uveoretinal Coloboma
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07632 LHX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LHX2 RGD RGD:71076
Felis catus LHX2 VGNC VGNC:102947
Macaca mulatta LHX2 VGNC VGNC:74262
Mus musculus LHX2 MGD MGI:96785
Canis familiaris LHX2 VGNC VGNC:42663
Bos taurus LHX2 VGNC VGNC:30872
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