NRF1 - nuclear respiratory factor 1 Gene

中文名称：核呼吸因子 1

种属: Homo sapiens

同用名: ALPHA-PAL

基因 ID: 4899 | 基因类型: protein coding

关于 NRF1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:129,611,720-129,757,076 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in ovary (RPKM 7.4), lymph node (RPKM 5.2) and 25 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质可同源二聚化并充当转录因子，可激活一些调节细胞生长和呼吸、血红素生物合成以及线粒体 DNA 转录和复制所需的核基因的关键代谢基因的表达。该蛋白质还与神经突生长的调节有关。可变剪接导致多个转录本变体。由于该基因的 NRF1 共享符号和“核因子 (红细胞衍生 2) 样 1” (其官方符号为 NFE2L1) ，在书目数据库中出现了混淆。[RefSeq 提供，2014 年 5 月]

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

NRF1 基因产物(4)

mRNA	Protein	Name
NM_001040110.2	NP_001035199.1	nuclear respiratory factor 1 isoform 1
NM_001293163.2	NP_001280092.1	nuclear respiratory factor 1 isoform 2
NM_001293164.2	NP_001280093.1	nuclear respiratory factor 1 isoform 3
NM_005011.5	NP_005002.3	nuclear respiratory factor 1 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	19674972	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	19674972	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19674972	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16864783	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	19674972	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NRF1 蛋白结构

Nrf1_DNA-bind

Nrf1_activ_bdg

0
100
200
300
400
503 a.a.

蛋白主名

其他名称

nuclear respiratory factor 1

alpha palindromic-binding protein

NRF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NRF1	Q16656	SP4	Homo sapiens	Q02446	Y2H Array	25416956
种属内	NRF1	Q16656	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	25416956
种属内	NRF1	Q16656	POGZ	Homo sapiens	Q7Z3K3	Y2H Array	25416956
种属内	NRF1	Q16656	POGZ	Homo sapiens	Q7Z3K3	Validated Y2H	25416956
种属内	NRF1	Q16656	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
种属内	NRF1	Q16656	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
种属内	NRF1	Q16656	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
种属内	NRF1	Q16656	FHL2	Homo sapiens	Q14192	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

NRF1 抗体

目录号	产品名	应用	反应物种
HY-P80769	Nrf1 Antibody	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ

Benign Peritoneal Mesothelioma

Mesothelioma Of Peritoneum

Benign Neoplasm Of Mesothelial Tissue Of Peritoneum

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-129225	WRR139		99.71%	否
HY-125535	OSU-53		/	否
HY-149127	Rosolutamide		/	否
HY-RS09567	NRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NRF1	VGNC	VGNC:43966
Rattus norvegicus	NRF1	RGD	RGD:1304603
Macaca mulatta	NRF1	VGNC	VGNC:81731
Mus musculus	NRF1	MGD	MGI:1332235
Felis catus	NRF1	VGNC	VGNC:68563
Bos taurus	NRF1	VGNC	VGNC:32260

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NRF1 - nuclear respiratory factor 1 Gene

关于 NRF1

功能概要

NRF1 基因产物(4)

NRF1 蛋白结构

NRF1 蛋白互作信息

NRF1 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

NRF1 - nuclear respiratory factor 1 Gene

关于 NRF1

功能概要

NRF1 基因产物(4)

NRF1 蛋白结构

NRF1 蛋白互作信息

NRF1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z