2. Gene
  3. MXD3 - MAX dimerization protein 3 Gene

MXD3 - MAX dimerization protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAX 二聚化蛋白 3

种属: Homo sapiens

同用名: MYX; MAD3; BHLHC13

基因 ID: 83463 | 基因类型: protein coding

关于 MXD3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,305,499-177,312,752 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.2), colon (RPKM 14.3) and 25 other tissues.

功能概要

该基因编码基本螺旋-环-螺旋亮氨酸拉链转录调节因子 Myc 超家族的成员。编码的蛋白质与辅因子 MAX 形成异二聚体，后者结合靶基因启动子中的特定 E-box DNA 基序并调节其转录。 MAX-MXD3 复合物的破坏与不受控制的细胞增殖和肿瘤发生有关。已经描述了编码不同亚型的该基因的转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

MXD3 基因产物(4)

mRNA Protein Name
NM_001142935.2 NP_001136407.1 max dimerization protein 3 isoform b
NM_001394986.1 NP_001381915.1 max dimerization protein 3 isoform a
NM_001394987.1 NP_001381916.1 max dimerization protein 3 isoform c
NM_031300.4 NP_112590.1 max dimerization protein 3 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MXD3 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (59 - 110)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

max dimerization protein 3

Max-associated protein 3

MXD3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MXD3 Q9BW11 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra MXD3 Q9BW11 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra MXD3 Q9BW11 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra MXD3 Q9BW11 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra MXD3 Q9BW11 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 TFIP11 Homo sapiens Q9UBB9
Anti Tag CoIP
33961781
Intra MXD3 Q9BW11 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra MXD3 Q9BW11 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra MXD3 Q9BW11 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra MXD3 Q9BW11 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra MXD3 Q9BW11 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra MXD3 Q9BW11 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra MXD3 Q9BW11 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra MXD3 Q9BW11 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra MXD3 Q9BW11 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra MXD3 Q9BW11 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra MXD3 Q9BW11 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra MXD3 Q9BW11 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra MXD3 Q9BW11 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra MXD3 Q9BW11 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atrichia With Papular Lesions

Papular Atrichia

APL

Congenital Atrichia
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08862 MXD3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MXD3 VGNC VGNC:55224
Macaca mulatta MXD3 VGNC VGNC:84451
Canis familiaris MXD3 VGNC VGNC:51904
Mus musculus MXD3 MGD MGI:104987
Rattus norvegicus MXD3 RGD RGD:628624
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