MXD3 - MAX dimerization protein 3 Gene

中文名称：MAX 二聚化蛋白 3

种属: Homo sapiens

同用名: MYX; MAD3; BHLHC13

关于 MXD3

功能概要

该基因编码基本螺旋-环-螺旋亮氨酸拉链转录调节因子 Myc 超家族的成员。编码的蛋白质与辅因子 MAX 形成异二聚体，后者结合靶基因启动子中的特定 E-box DNA 基序并调节其转录。 MAX-MXD3 复合物的破坏与不受控制的细胞增殖和肿瘤发生有关。已经描述了编码不同亚型的该基因的转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]