NME4 - NME/NM23 nucleoside diphosphate kinase 4 Gene

中文名称：NME/NM23 核苷二磷酸激酶 4

种属: Homo sapiens

同用名: NDPK-D; NM23H4; nm23-H4

基因 ID: 4833 | 基因类型: protein coding

关于 NME4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:396,729-400,754 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 37.4), fat (RPKM 31.4) and 25 other tissues.

功能概要

核苷二磷酸 (NDP) 激酶 (EC 2.7.4.6) 是一种普遍存在的酶，可通过磷酸组氨酸中间体在核苷和二氧核苷三磷酸和二磷酸之间催化 γ- 磷酸转移。这些酶是 nm23 基因家族的产物，其中包括 NME4 (Milon 等人，1997 [PubMed 9099850]) 。[OMIM 提供，2008 年 5 月]

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous Enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The Enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

NME4 基因产物(7)

mRNA	Protein	Name
NM_001286433.2	NP_001273362.1	nucleoside diphosphate kinase, mitochondrial isoform b
NM_001286435.2	NP_001273364.1	nucleoside diphosphate kinase, mitochondrial isoform c
NM_001286436.2	NP_001273365.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286438.2	NP_001273367.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286439.2	NP_001273368.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286440.2	NP_001273369.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_005009.3	NP_005000.1	nucleoside diphosphate kinase, mitochondrial isoform a precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cardiolipin binding	IDA IDA: 通过直接分析推断	23150663	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lipid transport	IDA IDA: 通过直接分析推断	23150663	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial intermembrane space	IDA IDA: 通过直接分析推断	23150663	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NME4 蛋白结构

NDK

0
100
187 a.a.

蛋白主名

其他名称

nucleoside diphosphate kinase, mitochondrial

NDK

NME4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NME4	O00746	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	NME4	O00746	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	NME4	O00746	CABP5	Homo sapiens	Q9NP86	Validated Y2H	32296183
Intra	NME4	O00746	POLR1C	Homo sapiens	O15160	Validated Y2H	32296183
Intra	NME4	O00746	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	NME4	O00746	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	NME4	O00746	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	NME4	O00746	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	NME4	O00746	TRAPPC2	Homo sapiens	P0DI81-3	Validated Y2H	32296183
Intra	NME4	O00746	CABP2	Homo sapiens	Q9NPB3	Validated Y2H	32296183
Intra	NME4	O00746	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	NME4	O00746	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	NME4	O00746	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	NME4	O00746	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	NME4	O00746	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	NME4	O00746	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	NME4	O00746	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	NME4	O00746	UBL5	Homo sapiens	Q9BZL1	Validated Y2H	32296183
Intra	NME4	O00746	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	NME4	O00746	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	NME4	O00746	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
Intra	NME4	O00746	ZBTB16	Homo sapiens	Q05516	Validated Y2H	32296183
Intra	NME4	O00746	NME2	Homo sapiens	P22392	Anti Tag CoIP	27499296
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Validated Y2H	32814053
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Y2H Pooling	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Validated Y2H	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Y2H Array	32814053
Intra	NME4	O00746	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	NME4	O00746	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	NME4	O00746	SUFU	Homo sapiens	Q9UMX1	Y2H Prey Pooling	32296183
Intra	NME4	O00746	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Anti Tag CoIP	27499296
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Prey Pooling	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Validated Y2H	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Array	31515488
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Array	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Prey Pooling	25416956
Intra	NME4	O00746	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	NME4	O00746	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	NME4	O00746	MLH1	Homo sapiens	P40692	Validated Y2H	32296183
Intra	NME4	O00746	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	NME4	O00746	CDKN2D	Homo sapiens	P55273	Validated Y2H	32296183
Intra	NME4	O00746	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	32296183
Intra	NME4	O00746	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	NME4	O00746	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09375	NME4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NME4	VGNC	VGNC:75358
Rattus norvegicus	NME4	RGD	RGD:1591334
Mus musculus	NME4	MGD	MGI:1931148

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NME4 - NME/NM23 nucleoside diphosphate kinase 4 Gene

关于 NME4

功能概要

NME4 基因产物(7)

NME4 蛋白结构

NME4 蛋白互作信息

直系同源

热门区域

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NME4 - NME/NM23 nucleoside diphosphate kinase 4 Gene

关于 NME4

功能概要

NME4 基因产物(7)

NME4 蛋白结构

NME4 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z