1. Gene
  2. CABP2 - calcium binding protein 2 Gene

CABP2 - calcium binding protein 2 Gene

中文名称:钙结合蛋白 2

种属: Homo sapiens

同用名: DFNB93

基因 ID: 51475 | 基因类型: protein coding

关于 CABP2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,518,912-67,523,446 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues, 20 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因属于与钙调蛋白具有相似性的钙结合蛋白亚家族。与钙调蛋白一样,这些家族成员可能会刺激钙调蛋白依赖性激酶 II 和蛋白磷酸酶钙调神经磷酸酶。钙结合蛋白是钙介导的细胞信号转导的重要组成部分。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2016 年 1 月]

This gene belongs to a subfamily of calcium binding proteins that share similarity to Calmodulin. Like Calmodulin, these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase Calcineurin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

CABP2 基因产物(2)

mRNA Protein Name
NM_001318496.2 NP_001305425.1 calcium-binding protein 2 isoform 3
NM_016366.3 NP_057450.2 calcium-binding protein 2 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
19338761 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19338761 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CABP2 蛋白结构

EF-hand_1

EF-hand_1: EF hand (82 - 110)

EF-hand_7

EF-hand_7: EF-hand domain pair (157 - 218)

  • 0
  • 100
  • 200
  • 220 a.a.
蛋白主名 其他名称

calcium-binding protein 2

CABP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CABP2 Q9NPB3 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 TEKT5 Homo sapiens Q96M29
Y2H Array
32296183
种属内
CABP2 Q9NPB3 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
种属内
CABP2 Q9NPB3 RD3 Homo sapiens Q7Z3Z2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 RD3 Homo sapiens Q7Z3Z2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 SPMIP6 Homo sapiens Q8NCR6
Y2H Array
32296183
种属内
CABP2 Q9NPB3 SPMIP6 Homo sapiens Q8NCR6
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 MXRA8 Homo sapiens Q9BRK3
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 MXRA8 Homo sapiens Q9BRK3
Y2H Array
32296183
种属内
CABP2 Q9NPB3 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 SPATC1L Homo sapiens Q9H0A9-2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 SPATC1L Homo sapiens Q9H0A9-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ZNF140 Homo sapiens P52738
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ZNF140 Homo sapiens P52738
Y2H Array
32296183
种属内
CABP2 Q9NPB3 VXN Homo sapiens Q8TAG6
Y2H Array
32296183
种属内
CABP2 Q9NPB3 VXN Homo sapiens Q8TAG6
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 CIMIP1 Homo sapiens Q9H1P6
Y2H Array
32296183
种属内
CABP2 Q9NPB3 CIMIP1 Homo sapiens Q9H1P6
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 PRR20D Homo sapiens P86480
Y2H Array
32296183
种属内
CABP2 Q9NPB3 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 UNKL Homo sapiens Q9H9P5-5
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NOP10 Homo sapiens Q9NPE3
Validated Y2H
32296183
种属内
CABP2 Q9NPB3 NOP10 Homo sapiens Q9NPE3
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NOP10 Homo sapiens Q9NPE3
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 HOXD12 Homo sapiens P35452-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ANKRD29 Homo sapiens Q8N6D5
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ANKRD29 Homo sapiens Q8N6D5
Y2H Array
32296183
种属内
CABP2 Q9NPB3 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
种属内
CABP2 Q9NPB3 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 DPEP2NB Homo sapiens A0A0U1RQF7
Y2H Array
32296183
种属内
CABP2 Q9NPB3 DPEP2NB Homo sapiens A0A0U1RQF7
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 NDUFAF3 Homo sapiens Q9BU61
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NDUFAF3 Homo sapiens Q9BU61
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
种属内
CABP2 Q9NPB3 COA6 Homo sapiens Q5JTJ3
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 COA6 Homo sapiens Q5JTJ3
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NUDT16L1 Homo sapiens Q9BRJ7
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 NUDT16L1 Homo sapiens Q9BRJ7
Y2H Array
32296183
种属内
CABP2 Q9NPB3 ZNF785 Homo sapiens A8K8V0
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ZNF785 Homo sapiens A8K8V0
Y2H Array
32296183
种属内
CABP2 Q9NPB3 THAP6 Homo sapiens Q8TBB0
Y2H Array
32296183
种属内
CABP2 Q9NPB3 THAP6 Homo sapiens Q8TBB0
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
种属内
CABP2 Q9NPB3 C22orf39 Homo sapiens Q6P5X5
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 C22orf39 Homo sapiens Q6P5X5
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NME4 Homo sapiens O00746
Y2H Array
32296183
种属内
CABP2 Q9NPB3 NME4 Homo sapiens O00746
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 TNNI1 Homo sapiens P19237
Y2H Array
32296183
种属内
CABP2 Q9NPB3 ADGRF5 Homo sapiens Q8IZF2
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ADGRF5 Homo sapiens Q8IZF2
Y2H Array
32296183
种属内
CABP2 Q9NPB3 ZNF57 Homo sapiens Q68EA5
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 ZNF57 Homo sapiens Q68EA5
Y2H Array
32296183
种属内
CABP2 Q9NPB3 AVPI1 Homo sapiens Q5T686
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 AVPI1 Homo sapiens Q5T686
Y2H Array
32296183
种属内
CABP2 Q9NPB3 SNAI2 Homo sapiens O43623
Y2H Prey Pooling
32296183
种属内
CABP2 Q9NPB3 SNAI2 Homo sapiens O43623
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 93

DFNB93

Autosomal Recessive Nonsyndromic Deafness 93

Autosomal Recessive Deafness 93

Deafness, Autosomal Recessive, 93

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 93

Deafness, Autosomal Recessive, Type 93

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Deafness, Autosomal Recessive
Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Deafness, Autosomal Dominant 2b

DFNA2B

Autosomal Dominant Nonsyndromic Deafness 2b

Autosomal Dominant Deafness 2b

Deafness, Autosomal Dominant, 2b

Deafness, Autosomal Dominant, Type 2b

Deafness, Autosomal Recessive 35

DFNB35

Autosomal Recessive Nonsyndromic Deafness 35

Autosomal Recessive Deafness 35

Deafness, Autosomal Recessive, 35

Deafness, Autosomal Recessive, Type 35

Deafness, Autosomal Recessive 6

DFNB6

Neurosensory Nonsyndromic Recessive Deafness 6

Nsrd6

Autosomal Recessive Nonsyndromic Deafness 6

Autosomal Recessive Deafness 6

Deafness, Autosomal Recessive, 6

Deafness Neurosensory Autosomal Recessive 6

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 6

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 6

Deafness, Autosomal Recessive, Type 6

Deafness, Autosomal Recessive 67

DFNB67

Autosomal Recessive Nonsyndromic Deafness 67

Autosomal Recessive Deafness 67

Deafness, Autosomal Recessive, 67

Deafness, Autosomal Recessive, Type 67

Charcot-Marie-Tooth Disease X-Linked Recessive 4

Cmt4x

Cmtx4

Cowchock Syndrome

X-Linked Charcot-Marie-Tooth Disease Type 4

Axonal Motor Sensory Neuropathy With Deafness And Mental Retardation

Charcot-Marie-Tooth Disease With Deafness And Mental Retardation

Nadmr

Namsd

Melkersson-Rosenthal Syndrome

Melkersson Syndrome

Mros

Mrs

Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal

Melkersson'S Syndrome

Cheilitis Granulomatosa

Granulomatous Cheilitis

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis

Erythrokeratodermia Variabilis Et Progressiva

Greither Disease

Ekv

Ekvp

PSEK

Erythrokeratodermia Variabilis With Erythema Gyratum Repens

Keratosis Palmoplantaris Transgrediens Et Progrediens

Transgrediens Et Progrediens Palmoplantar Keratoderma

EKVP1

Erythrokeratodermia, Progressive Symmetric

Erythrokeratodermia Figurata, Congenital Familial, In Plaques

Keratoderma Palmoplantaris Transgrediens

Keratosis Extremitatum Hereditaria Progrediens

Erythrokeratodermia Variabilis, Mendes Da Costa Type

Progressive Symmetric Erythrokeratodermia

Erythrokeratodermia Figurata Variabilis

Greither'S Disease

Ekv-P

Erythrokeratodermia Variabilis Of Mendes Da Costa

Progressive Symmetrical Erythrokeratoderma Of Gottron

Progressive Diffuse Ppk

Progressive Diffuse Palmoplantar Keratoderma

Transgrediens Et Progrediens Ppk

Darier-Gottron Disease

Erythrokeratodermia Progressiva Symmetrica

Progressive Symmetric Erythrokeratodermia, Gottron Type

Congenital Familial Erythrokeratodermia Figurata In Plaques

Erythrokeratodermia Progressive Symmetric

Erythrokeratodermia Variabilis Mendes Da Costa Type

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CABP2 VGNC VGNC:60286
Mus musculus CABP2 MGD MGI:1352749
Macaca mulatta CABP2 VGNC VGNC:70496
Rattus norvegicus CABP2 RGD RGD:1563670
Canis familiaris CABP2 VGNC VGNC:38624
Bos taurus CABP2 VGNC VGNC:26665