2. Gene
  3. NME2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

NME2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NME/NM23 核苷二磷酸激酶 2

种属: Homo sapiens

同用名: PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2

基因 ID: 4831 | 基因类型: protein coding

关于 NME2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:51,165,536-51,171,744 (from NCBI)

This gene has 9 transcripts (splice variants), 118 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues.

功能概要

核苷二磷酸激酶 (NDK) 以六聚体形式存在，由“A” (由 NME1 编码) 和“B” (由该基因编码) 亚型组成。已发现该基因的多个选择性剪接转录物变体。来自邻近上游基因 (NME1) 的通读转录生成天然存在的转录本 (NME1-NME2) ，该转录本编码一种融合蛋白，该融合蛋白由与每个单独基因产物共享同一性的序列组成。[RefSeq 提供，2010 年 11 月]

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

NME2 基因产物(5)

mRNA Protein Name
NM_001018137.3 NP_001018147.1 nucleoside diphosphate kinase B isoform a
NM_001018138.1 NP_001018148.1 nucleoside diphosphate kinase B isoform a
NM_001018139.2 NP_001018149.1 nucleoside diphosphate kinase B isoform a
NM_001198682.2 NP_001185611.1 nucleoside diphosphate kinase B isoform b
NM_002512.4 NP_002503.1 nucleoside diphosphate kinase B isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
19435876 GOA
enables G-quadruplex DNA binding IDA
IDA: 通过直接分析推断
25679041 GOA
enables GDP binding IMP
IMP: 通过突变表型推断
19435876 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
enables nucleoside diphosphate kinase activity IDA
IDA: 通过直接分析推断
1851158 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11919189 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
8392752 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
11919189 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16862176 GOA
involved in nucleoside triphosphate biosynthetic process IDA
IDA: 通过直接分析推断
1851158 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8392752 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19435876 GOA
involved in positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
16862176 GOA
involved in positive regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
16862176 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15703214 GOA
involved in regulation of epidermis development IMP
IMP: 通过突变表型推断
16862176 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
11919189 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15703214 GOA
NOT located in focal adhesion IDA
IDA: 通过直接分析推断
11919189 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
11919189 GOA
located in ruffle IDA
IDA: 通过直接分析推断
11919189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nucleoside diphosphate kinase B

HEL-S-155an

NME2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NME2 P22392 ITGB1BP1 Homo sapiens O14713-1
Anti Bait CoIP
11919189
种属内
NME2 P22392 ITGB1BP1 Homo sapiens O14713-1
Pull Down
11919189
种属内
NME2 P22392 ITGB1BP1 Homo sapiens O14713-1
ELISA
11919189
种属内
NME2 P22392 NME3 Homo sapiens Q13232
Anti Tag CoIP
33961781
种属内
NME2 P22392 NME2 Homo sapiens P22392
Anti Tag CoIP
33961781
种属内
NME2 P22392 NME2 Homo sapiens P22392
Y2H
21988832
种属内
NME2 P22392 NME4 Homo sapiens O00746
Y2H
21988832
种属内
NME2 P22392 NME1 Homo sapiens P15531
Pull Down
17314099
种属内
NME2 P22392 NME4 Homo sapiens O00746
Anti Tag CoIP
33961781
种属内
NME2 P22392 NME1 Homo sapiens P15531
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

NME2 抗体

目录号 产品名 应用 反应物种
HY-P83223 NME2 Antibody (YA2968) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Endometrium Carcinoma In Situ

Carcinoma In Situ Of Endometrium

Endometrial Carcinoma In Situ
Nemaline Myopathy 2

NEM2

Nemaline Myopathy 2, Autosomal Recessive

Nemaline Myopathy, Type 2

Neb-Related Nemaline Myopathy

Myopathy, Nemaline, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N6747 Stauprimide Inhibitor 99.45% 否
HY-170436 NFh-NMe-2 Inducer / 否
HY-RS09372 NME1-NME2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09373 NME2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W591768 (E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NME2 VGNC VGNC:108102
Rattus norvegicus NME2 RGD RGD:619877
Mus musculus NME2 MGD MGI:97356
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