CIB1 - calcium and integrin binding 1 Gene

中文名称：钙和整合素结合 1

种属: Homo sapiens

同用名: CIB; CIBP; KIP1; PRKDCIP; SIP2-28

基因 ID: 10519 | 基因类型: protein coding

关于 CIB1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,229,975-90,265,759 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 49.7), adrenal (RPKM 37.7) and 25 other tissues.

功能概要

该基因编码包含 EF-hand 结构域的钙结合超家族的成员。编码的蛋白质与许多其他蛋白质相互作用，包括血小板整合素 alpha-IIb-beta-3、DNA 依赖性蛋白激酶、早老素-2、粘着斑激酶、p21 激活激酶和蛋白激酶 D。编码的蛋白质可能参与其中影响细胞存活和增殖，并与包括癌症和阿尔茨海默氏病在内的多种疾病状态相关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 4 月]

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many Other proteins, including the platelet Integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including Cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CIB1 基因产物(2)

mRNA	Protein	Name
NM_001277764.2	NP_001264693.1	calcium and integrin-binding protein 1 isoform a
NM_006384.4	NP_006375.2	calcium and integrin-binding protein 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IMP IMP: 通过突变表型推断	15475008	GOA
enables calcium-dependent protein kinase inhibitor activity	IMP IMP: 通过突变表型推断	20473878	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10366599	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: 通过直接分析推断	20473878	GOA
enables protein-membrane adaptor activity	IGI IGI: 通过遗传相互作用推断	20639889	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	11756406	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	12011095	GOA
involved in apoptotic process	IMP IMP: 通过突变表型推断	10366599	GOA
involved in cellular response to nerve growth factor stimulus	IDA IDA: 通过直接分析推断	21215777	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: 通过突变表型推断	19854831	GOA
involved in cytoplasmic microtubule organization	IMP IMP: 通过突变表型推断	20951827	GOA
involved in endomitotic cell cycle	IDA IDA: 通过直接分析推断	21264284	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	19854831	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	21264284	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: 通过直接分析推断	21215777	GOA
involved in negative regulation of neuron projection development	IDA IDA: 通过直接分析推断	21215777	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	19854831	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IDA IDA: 通过直接分析推断	20639889	GOA
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: 通过直接分析推断	11756406	GOA
involved in positive regulation of protein localization to plasma membrane	IGI IGI: 通过遗传相互作用推断	20639889	GOA
involved in positive regulation of protein targeting to membrane	IMP IMP: 通过突变表型推断	19854831	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: 通过直接分析推断	11756406	GOA
involved in regulation of cell division	IMP IMP: 通过突变表型推断	20951827	GOA
involved in regulation of cell population proliferation	IMP IMP: 通过突变表型推断	20951827	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell periphery	IDA IDA: 通过直接分析推断	11756406	GOA
located in centrosome	IDA IDA: 通过直接分析推断	20951827	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11756406	GOA
located in cytoplasm	IMP IMP: 通过突变表型推断	10366599	GOA
located in endoplasmic reticulum	IMP IMP: 通过突变表型推断	10366599	GOA
located in filopodium tip	IDA IDA: 通过直接分析推断	20951827	GOA
located in growth cone	IDA IDA: 通过直接分析推断	21215777	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	21215777	GOA
located in membrane	IDA IDA: 通过直接分析推断	10366599	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	21215777	GOA
located in neuronal cell body	IDA IDA: 通过直接分析推断	21215777	GOA
located in nucleoplasm	IMP IMP: 通过突变表型推断	10366599	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11756406	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	11756406	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	19854831	GOA
located in sarcolemma	IDA IDA: 通过直接分析推断	20639889	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CIB1 蛋白结构

EF-hand_7

0
100
191 a.a.

蛋白主名

其他名称

calcium and integrin-binding protein 1

DNA-PK interaction protein

CIB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CIB1	Q99828	SCAF1	Homo sapiens	Q9H7N4	Validated Y2H	32296183
种属内	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Pull Down	19805025
种属内	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	19805025
种属内	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Y2H	19805025
种属内	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Pull Down	21215777
种属内	CIB1	Q99828	STMN2	Homo sapiens	Q93045	PLA	21215777
种属内	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Y2H	21215777
种属内	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Confocal	21215777
种属内	CIB1	Q99828	WASL	Homo sapiens	O00401	Anti Bait CoIP	16582881
种属内	CIB1	Q99828	WASL	Homo sapiens	O00401	SPR	16582881
种属内	CIB1	Q99828	WASL	Homo sapiens	O00401	Anti Tag CoIP	16582881
种属内	CIB1	Q99828	WASL	Homo sapiens	O00401	Y2H	16582881

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epidermodysplasia Verruciformis 3

Epidermodysplasia Verruciformis, Susceptibility To, 3

EV3

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Usher Syndrome, Type Ij

Usher Syndrome Type 1j	USH1J
Usher Syndrome Type Ij	Usher Syndrome 1j
Usher'S Syndrome Type 1j

Skin Carcinoma

Skin Cancer	Carcinoma Of Skin
Ca - Skin Cancer	Cancer Of Skin
Malignant Neoplasm Of Skin	Melanoma And Non-Melanoma Skin Cancer
Skin Cancers	Cancer, Skin

Schneiderian Carcinoma

Cylindrical Cell Carcinoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-162558	NCGC00351170	Inhibitor	99.05%	否
HY-163805	UNC10245380		/	否
HY-RS02706	CIB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CIB1	VGNC	VGNC:71189
Mus musculus	CIB1	MGD	MGI:1344418
Felis catus	CIB1	VGNC	VGNC:60898
Canis familiaris	CIB1	VGNC	VGNC:39266
Bos taurus	CIB1	VGNC	VGNC:27359
Rattus norvegicus	CIB1	RGD	RGD:620133

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CIB1 - calcium and integrin binding 1 Gene

关于 CIB1

功能概要

CIB1 基因产物(2)

CIB1 蛋白结构

CIB1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CIB1 - calcium and integrin binding 1 Gene

关于 CIB1

功能概要

CIB1 基因产物(2)

CIB1 蛋白结构

CIB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z