1. Gene
  2. AUNIP - aurora kinase A and ninein interacting protein Gene

AUNIP - aurora kinase A and ninein interacting protein Gene

中文名称:极光激酶 A 和尼宁相互作用蛋白

种属: Homo sapiens

同用名: AIBP; C1orf135

基因 ID: 79000 | 基因类型: protein coding

关于 AUNIP

This gene has 3 transcripts (splice variants) and 91 orthologues. Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues.

功能概要

启用受损的 DNA 结合活性。通过同源重组参与双链断裂修复;通过非同源末端连接对双链断裂修复进行负调控;和主轴组织。位于中心体; DNA 损伤部位;和主轴杆。 [由基因组资源联盟提供,2022 年 4 月]

Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

AUNIP 基因产物(2)

mRNA Protein Name
NM_001287490.2 NP_001274419.1 aurora kinase A and ninein-interacting protein isoform 1
NM_024037.3 NP_076942.1 aurora kinase A and ninein-interacting protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables damaged DNA binding IDA
IDA: 通过直接分析推断
29042561 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20596670 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
29042561 GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
29042561 GOA
involved in spindle organization IMP
IMP: 通过突变表型推断
20596670 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
20596670 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
29042561 GOA
located in spindle pole IDA
IDA: 通过直接分析推断
20596670 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AUNIP 蛋白结构

AIB

AIB: Aurora kinase A and ninein interacting protein (26 - 350)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

aurora kinase A and ninein-interacting protein

aurora A-binding protein

AUNIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
种属内
AUNIP Q9H7T9 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
种属内
AUNIP Q9H7T9 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
33961781
种属内
AUNIP Q9H7T9 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
28514442
种属内
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
AUNIP Q9H7T9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
AUNIP Q9H7T9 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
AUNIP Q9H7T9 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
AUNIP Q9H7T9 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
AUNIP Q9H7T9 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
种属内
AUNIP Q9H7T9 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属内
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Validated Y2H
32814053
种属内
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Y2H Array
32814053
种属内
AUNIP Q9H7T9 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Apocrine Carcinoma

Apocrine Carcinoma Of Breast

Apocrine Breast Carcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus AUNIP MGD MGI:1917135
Rattus norvegicus AUNIP RGD RGD:1589922
Canis familiaris AUNIP VGNC VGNC:38309
Bos taurus AUNIP VGNC VGNC:26347
Felis catus AUNIP VGNC VGNC:60041
Macaca mulatta AUNIP VGNC VGNC:70140