2. Gene
  3. VPS28 - VPS28 subunit of ESCRT-I Gene

VPS28 - VPS28 subunit of ESCRT-I Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ESCRT-I 的 VPS28 亚基

种属: Homo sapiens

基因 ID: 51160 | 基因类型: protein coding

关于 VPS28

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,423,617-144,428,548 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele and 191 orthologues. Ubiquitous expression in ovary (RPKM 46.0), duodenum (RPKM 44.3) and 25 other tissues.

功能概要

该基因编码 ESCRT-I 复合物 (运输所需的内体复合物) 的蛋白质亚基，其在将蛋白质运输和分类到亚细胞囊泡中发挥作用。这种复合物也可以被劫持以促进包膜病毒从细胞膜中出芽。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

VPS28 基因产物(2)

mRNA Protein Name
NM_016208.4 NP_057292.1 vacuolar protein sorting-associated protein 28 homolog isoform 1
NM_183057.3 NP_898880.1 vacuolar protein sorting-associated protein 28 homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11134028 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
11916981 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
18077552 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
11916981 GOA
involved in positive regulation of ubiquitin-dependent endocytosis IMP
IMP: 通过突变表型推断
11916981 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
21757351 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT I complex IDA
IDA: 通过直接分析推断
18005716 GOA
part of ESCRT I complex IPI
IPI: 通过物理相互作用推断
18005716 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18077552 GOA
located in cytosol IDA
IDA: 通过直接分析推断
11134028 GOA
located in early endosome IDA
IDA: 通过直接分析推断
11916981 GOA
located in endosome IDA
IDA: 通过直接分析推断
11134028 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
11134028 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17940959 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS28 蛋白结构

VPS28

VPS28: VPS28 protein (39 - 220)

  • 0
  • 100
  • 200
  • 221 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 28 homolog

ESCRT-I complex subunit VPS28

VPS28 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VPS28 Q9UK41 MBIP Homo sapiens Q9NS73-5
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 MBIP Homo sapiens Q9NS73-5
Validated Y2H
26871637
Intra VPS28 Q9UK41 MBIP Homo sapiens Q9NS73-5
Y2H Array
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-2
Validated Y2H
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-2
Y2H Array
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-2
BiFC
26871637
Intra VPS28 Q9UK41 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 TCF12 Homo sapiens Q99081-3
Validated Y2H
26871637
Intra VPS28 Q9UK41 TCF12 Homo sapiens Q99081-3
Y2H Array
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-3
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-3
Validated Y2H
26871637
Intra VPS28 Q9UK41 CARD9 Homo sapiens Q9H257-3
Y2H Array
26871637
Intra VPS28 Q9UK41 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
26871637
Intra VPS28 Q9UK41 BLZF1 Homo sapiens Q9H2G9
Y2H Array
26871637
Intra VPS28 Q9UK41 VPS52 Homo sapiens Q8N1B4
Validated Y2H
26871637
Intra VPS28 Q9UK41 VPS52 Homo sapiens Q8N1B4
Y2H Array
26871637
Intra VPS28 Q9UK41 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 SKIL Homo sapiens P12757
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 SKIL Homo sapiens P12757
Validated Y2H
26871637
Intra VPS28 Q9UK41 SKIL Homo sapiens P12757
Y2H Array
26871637
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Anti Tag CoIP
33961781
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Pooling
19060904
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Anti Tag CoIP
35271311
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Array
19060904
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Validated Y2H
26871637
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Anti Tag CoIP
28514442
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Array
25416956
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 TSG101 Homo sapiens Q99816
Y2H Array
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637
Validated Y2H
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637
Y2H Array
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637
BiFC
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637-3
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637-3
Validated Y2H
26871637
Intra VPS28 Q9UK41 SMN1 Homo sapiens Q16637-3
Y2H Array
26871637
Intra VPS28 Q9UK41 SAXO1 Homo sapiens Q8IYX7
Y2H Array
26871637
Intra VPS28 Q9UK41 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
26871637
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Validated Y2H
26871637
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Y2H Array
31515488
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Y2H Array
26871637
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Anti Tag CoIP
33961781
Intra VPS28 Q9UK41 VPS37B Homo sapiens Q9H9H4
Anti Tag CoIP
28514442
Intra VPS28 Q9UK41 GOLGA2 Homo sapiens Q08379
Validated Y2H
26871637
Intra VPS28 Q9UK41 GOLGA2 Homo sapiens Q08379
Y2H Array
26871637
Intra VPS28 Q9UK41 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 TRIM27 Homo sapiens P14373
Y2H Array
26871637
Intra VPS28 Q9UK41 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 TRIM27 Homo sapiens P14373
Validated Y2H
26871637
Intra VPS28 Q9UK41 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra VPS28 Q9UK41 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
26871637
Intra VPS28 Q9UK41 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra VPS28 Q9UK41 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
26871637
Intra VPS28 Q9UK41 RASSF5 Homo sapiens Q8WWW0-2
Validated Y2H
26871637
Intra VPS28 Q9UK41 RASSF5 Homo sapiens Q8WWW0-2
Y2H Prey Pooling
26871637
Intra VPS28 Q9UK41 RASSF5 Homo sapiens Q8WWW0-2
Y2H Array
26871637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 80, Autosomal Dominant

SPG80

Hereditary Spastic Paraplegia 80

Spastic Paraplegia 80 Autosomal Dominant

Doid:0112341
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3

Frontotemporal Dementia, Chromosome 3-Linked

Amyotrophic Lateral Sclerosis, Chmp2b-Related

Chromosome 3-Linked Frontotemporal Dementia

FTDALS7

Chmp2b-Related Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 17, Formerly

Als17, Formerly

Amyotrophic Lateral Sclerosis Type 17

Dtm1

Ftd-3

Ftd-Chmp2b

Als17

Amyotrophic Lateral Sclerosis 17

Sclerosis, Lateral, Amyotrophic, Type 17

Dementia, Frontotemporal, Chromosome 3-Linked
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15681 VPS28 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus VPS28 MGD MGI:1914164
Macaca mulatta VPS28 VGNC VGNC:79116
Canis familiaris VPS28 VGNC VGNC:48282
Bos taurus VPS28 VGNC VGNC:54396
Rattus norvegicus VPS28 RGD RGD:1306537
Felis catus VPS28 VGNC VGNC:66963
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